and Laboratory Methods. 2025 



Sabrareset Muratet. Sarcomatose de L'Hy- Many multiple tumors of the skin have 

 poderme avec Generalisation Mesoderm- , , -i j rr-i , 



ique. Archiv. de Med. Exper. 14: 203-220, been described. The sarcomata form 



i9°2- the largest class of these. They have 



been separated by Perrin into (1) sarcomata, primary and secondary, melanotic 

 in form, and (2) sarcomata non-melanotic. He further subdivides these two 

 great divisions. In the second class we find the cutaneous and subcutaneous 

 forms. The first variety has been well described by Kaposi and others. The 

 second form presents marked differences. Its course is more rapid, and the 

 prognosis is always fatal. Pauzier, Lapeyre and Labbe have given this class 

 some attention, and Sabrazes and Muratet describe a case. The patient was a 

 man, aged sixty-six, who presented many of these subcutaneous sarcomata. 

 The onset was insidious, a small nodule being noted in the right subclavicular 

 fossa. Other nodules were soon observed, especially over the abdomen and 

 back. Death ensued in eight months. These tumors were accompanied by 

 progressive emaciation, malaise, slight jaundice and marked anaemia. A vigorous 

 treatment with arsenic improved this anaemia somewhat. At the autopsy nodules 

 varying in size were found in the regions above noted, in the cellular adipose 

 tissue of the kidneys, in the omentum, the pericardium, the myocardium and the 

 cavities of the heart. They were only noted in mesodermic tissues. Micro- 

 scopically these nodules, were mostly made up of round and fusiform cells, though 

 intermediate forms were also noted. The nucleus had generally one nucleolus, 

 but several were at times seen. Occasionally two nuclei were in the same cells. 

 Karyokinetic figures were quite abundant. Plasma cells were but rarely noted. 

 The nodules were quite vascular, and extravasations of blood into the tissues 

 were frequently observed. Haemosiderin, the iron containing blood pigment, 

 was present intra- and extra-cellularly in these nodules. w. r. s. 



,. „. , T,, .. r J ,»T 1 Myelocytes in acute infectious diseases 



Zmno. Em seltener Blutbefund (Myelocy- ^ ^ 



tamie) in zwei Fallen von Pest. Centralbl. have been found by different investi- 



f. allg. Path. u. path. Anat. 13: 410-412, gators. Turk observed those with 

 1902. ° 



neutrophile granulations in many such 



diseases, especially in pneumonia; Those with eosinophile granules he found 

 but rarely. French observers have worked in this field, but they do not give the 

 variety of myelocytes found. Zinno relates two cases of bubonic plague which 

 showed considerable numbers of eosinophilic myelocytes. In the first case, 

 which resulted fatally, the blood was obtained on the third and fourth days of the 

 disease. The red blood corpuscles were reduced to 3,800,000 while the leucocytes 

 were 6000 (4000 of these being polymorphonuclears and 2000 mononuclears). 

 The small mononuclear leucocytes composed about two-thirds of all the mono- 

 nuclear forms, and eosinophilic myelocytes were present to the amount of 1-1.5 

 per cent, of all the leucocytes counted. In the second case the blood examina- 

 tions were made on the eighth and ninth days of the disease. The red blood 

 corpuscles were 3,600,000, while the white blood corpuscles were 38,000 (21,000 

 *of these being polymorphonuclears and 17,000 mononuclears). Of the mono- 

 nuclear forms the small mononuclears predominated. Eosinophilic myelo- 

 cytes were present to the amount of 13 per cent. At times the eosinophilic 

 leucocytes appeared to take their origin from them. The patient made a good 

 recovery, and in a subsequent blood examination these leucocytes were found to 

 amount to 13 per cent., while the myelocytes were very few. The presence of 

 these eosinophilic myelocytes may be of some diagnostic importance. 



w. R. s. 



