2066 Journal of Applied Microscopy 



Glogner is unable to explain the cause of Framboesia. Many sections were 

 stained for bacteria, and countless methods were employed — all with negative 

 results, however. Blastomyces were in vain looked for with special staining 

 reactions. Pierez, Nicholis and Watts, however, have described and cultivated 

 bacteria as the causal agents of this disease. By inoculation Lange, Morris and 

 Steele obtained negative results, but Charlouis, though successful in causing 

 some lesion, was unable to reproduce the disease. w. r. s. 



Brault. LeGlycogeneHepatiquedanslesCirr- Contrary to the expectation that the 

 hoses. Archiv. de Med. Experiment, et glycogenic function of the liver would 

 ■' * ^^ 4 9' 9 • j^g suspended in cirrhosis, Brault has 



found that it is well maintained. He gives the clinical histories, with the 

 autopsy findings, of five cases. In three of these tuberculosis was a complica- 

 tion, in one the cirrhosis was latent, the patient dying of pneumonia, while in 

 another death was due to the rupture of some oesophageal varices. The autop- 

 sies were performed from three to thirty-six hours after death, and in all of them 

 the liver was found to possess a great number of cells, intact or fatty, contain- 

 ing glycogen. This reaction was obtainable even in fragments of lobules that 

 were entirely isolated by surrounding connective tissue. The glycogen was 

 never uniformly shared by all the cells in the lobule. In one case the cells in 

 the center of the lobule were fatty, while those in the intermediary zone con- 

 tained both fat droplets and glycogen. In the peripheral zone or peri-portal 

 region the glycogen was found in the greatest amount. In another case the 

 reaction was obtained after an antiseptic fluid had been injected into the peri- 

 toneal cavity to prevent putrefaction. 



Brault concludes that the pressure exerted by connective tissue on isolated 

 cells has no effect on their glycogenic function ; that it makes no difference in 

 the finding of glycogen whether the cells are fatty or not, or whether they have 

 their usual dimensions or are decreased in volume. These cells may be found 

 in lobules or isolated and apart by themselves. He inclines more to the view 

 that the presence of glycogen in cirrhosis is supplemental and vicarious rather 

 than physiological. Its excessive formation in this condition is due to some 

 nutritive excitation, and for a certain number of cells is only temporary, as these 

 cells subsequently undergo degenerative changes and disappear. w. r. s. 



Drake. Trichinosis. J. of Med. Research, 8: Since Brown first noted the presence 

 S5-- 7. 9 • Qf 2^jj eosinophilia in Trichinosis it has 



been an important diagnostic symptom in over twenty-five cases. The only 

 exception h^^ been Da Costa's case, reported a year ago. Its absence in the 

 case may have been due, as Coplin pointed out, to the fact that the patient was 

 not seen in the original attack but in a recrudescence of the disease. 



Drake did differential blood counts on 15 trichinous and 15 non-trichinous 

 swine. He found a varying percentage of eosinophiles, which, on the average, 

 was one per cent, lower in the trichinous than the non-trichinous swine. He 

 then relates the clinical histories of four cases of trichinosis which showed no 

 eosinophilia. In each case a portion of muscle had been excised and trichinae 

 found therein. In his conclusions he states that eosinophilia may not be pres- 

 ent during the course and recrudescences of the disease and that its absence by 

 no means eliminates the possibility of trichinosis being present. w. r. s. 



