352 Journal of Applied Microscopy. 



NORMAL AND PATHOLOGICAL HISTOLOGY. 



Richard M. Pearce, M. D. 



Pathological Laboratory, Boston City Hospital, Boston, Mass., to whom all books and papers 

 on these subjects should be sent for review. 



CURRENT LITERATURE. 



Krompecher. BeitrJige zur Lehre von den Krompecher agrees with those who 

 Plasmazellen. Ziegler's Beitrage, 24: Heft, i consider the plasma cells to be infiltra- 

 tion cells, and derived from lymphoid cells, but also thinks that a larger form 

 may possibly be derived from multinuclear leucocytes. He considers the pres- 

 ence of plasma cells to indicate a progressive activity. He has seen all stages 

 of transition between plasma cells and epithelioid cells, and thinks that plasma 

 cells are concerned in the formation of connective tissue. R. m. p. 



Fuerst. The Changes Produced in Epithelium F^^rst, working under Ribbert, de- 

 by Moderate Degrees of Heat and Cold. scribes the following changes in the 



Beitrgiie zur Path. Anat., i8nS. r i i •. i • • r* 



^ ^ ears of rabbits and guinea-pigs after 



freezing lightly with ether spray, or using water at about 50 C. The epidermis is 

 increased to eight times its normal thickness by an increase in the size of the 

 cells and by the formation of new cells. Many giant cells, formed by multiple 

 direct division of single cells, appear among the epithelial cells. Regenera- 

 tion of tissue from an injury, produced after exposure to heat or cold, takes place 

 three times as rapidly as normally. .Slight chemical irritation produces similar 

 proliferation, but no giant cell formation. He considers the rapid proliferation 

 to be due not to any peculiar action of the thermal or chemical irritant, but to 

 excessive regeneration. His explanation of the formation of giant cells is inter- 

 esting. He holds that by the thermic irritation the protoplasm of the cell is 

 injured, while the nucleus is intact. The injury to the protoplasm prevents true 

 karyokinesis, but allows unlimited direct nuclear division. R. m. p. 



Thomas. Med. and Surg. Reports of the Bos- Thomas reports a case of the formation 

 ton City Hospital, 1899. of ti-^g ^Qne in the brain, resulting from 



the presence of Coccidium oviforme. The tumor had caused no symptoms during 

 life. At the autopsy a small calcareous mass was found in the anterior central 

 convolution, which was atrophied. This mass, on microscopical examination, 

 was found to consist of true bone, with laminations, lacuna;, and canaliculi, con- 

 taining marrow spaces, with cedematous connective tissue, and occasional large 

 granular connective tissue cells (fat granule cells). Outside of the bone was a 

 layer of increased neuroglia tissue, a secondary gliosis. Near the nodule were 

 also seen long, spindle-shaped spaces surrounded by connective tissue cells, and 

 giant cells, the whole resembling the granulation tissue sometimes seen around fat 

 crystals. In the center of the nodule was a large space filled with granular 

 detritus in which were many small oval bodies.' These bodies, the coccidia, 

 had a distinct capsule, occasionally double, and were either empty or filled with 

 granular material. k. m. p. 



