480 Journal of Applied Microscopy. 



be found as late as the seventeenth day in the injected nerve. Wherever the 

 cocci become localized, there is a diffuse granular degeneration of the nerve 

 elements, followed by immigration of leucocytes, and a proliferation of cells of 

 the endoneurium and nerve sheaths. Later sclerotic changes occur. Degener- 

 ative changes are found in the ganglia of the dorsal nerve roots. The changes 

 are practically the same whether the injection is made into the nerve or into the 

 cord, and changes produced by the injection of the toxine are similar to those 

 produced by the injection of the cocci. The writers believe that their investiga- 

 tions furnish an anatomical basis for the theory of an ascending neuritis. 



^ ^ Fifteen minutes after an intratracheal injection of the strep- 



Silfvast. Lung. 1 1 , • , 



tococcus, the epithelial cells of the lung are studded with 



cocci which they have taken up. The phagocytosis of these cells is more 

 marked than that of the polymorphonuclear and large mononuclear leucocytes. 

 No streptococci can be found in the lung after twelve days, but they are demon- 

 strable in the bronchial lymph nodes up to the thirty-fifth day. The inflammatory 

 changes produced by the cocci and by their toxine are similar, and are at first 

 local and later diffuse. By the continued administration of toxine, the affected 

 areas undergo connective tissue changes. 



„.•• . ' . In all cases of general infection, irrespective of the method of 



Bjorksten. Liver. ° . ... 



inoculation, cocci are found in the capillaries of the liver, in 



all animals dying early, but not in those dying after the thirteenth day. The liver 



cells near these clumps of cocci are often changed. Sometimes necrosis, round 



cell infiltration, and hEemorrhages are found. After direct injection into the liver 



substance, the animal generally dies of acute peritonitis or of general infection. 



By injection through the common bile duct it is found possible to produce an 



infection of the liver, without marked general infection. In these cases the cocci 



are found in or about the bile passages where there is much small cell infiltration. 



Degeneration of the surrounding liver cells is seen ; later there is an increase of 



connective tissue in these areas, leading finally to complete cirrhosis. 



„ „ . , ,^ Direct injection of streptococcus into the heart muscle pro- 



Tallquist. Heart. ^ *^ . . 



duces, in nearly all cases, a pericarditis fatal in from two to 



three days. In the heart muscle small abscesses develop in some cases. More 



often, however, there are small foci made up of necrotic muscle fibers, round 



cells, and cocci. Small haemorrhages are frequent. Simple parenchymatous 



changes are seldom seen. After intravenous (ear vein) injections, changes 



in the muscles are quite constant. In addition to the changes produced by 



direct injections into the heart muscle, there is also seen, in some cases, hyalin 



degeneration of the muscle fibers, and proliferation of muscle nuclei. Interstitial 



changes are not uncommon in late cases. After intravenous injections of the 



toxine, granular, hyalin, and waxy degeneration of muscle fibers is seen. The 



interventricular septum and the wall of the left ventricle are the parts most 



commonly affected. 



The appearance of cocci in the urine is not constant. The 

 Bornsdorff. Kidney. ^^ . , , ,. , r ■ ■ ■ 



shortest time was nine and a half hours after injection. 



In five cases, with a fatal termination after periods varying from seven to 



