^-6 Journal of Applied Microscopy. 



grams and appeared normal. The heart weighed 450, the liver 3530, the spleen 

 450, and the kidneys 300 grams. 



Anatomical Diagnosis. — Lobar pneumonia, fibrinous pleuritis ; cirrhosis of 

 the liver ; softening of hypophysis, enlargement of viscera. 



Histological examination of the hypophysis showed the condition to be a 

 hyperplasia. In the mesenteric lymph nodes, spleen, pancreas, adrenals, and 

 thyroid an increase of connective tissue was observed. 



A careful description, with measurements, of the cranium and long bones, is 

 given. 



The second part of the paper is a very complete resume' by Le Count con- 

 cerning the pathological anatomy of acromegaly. 



In concluding, the writer lays down the following propositions as those which 

 have acquired the most prominence in the elucidation of the pathogenesis of 

 acromegaly : 



1. The cases of acromegaly associated with true tumor of the hypophysis 

 are certainly not as numerous as has been heretofore supposed. 



2. There is not as much constancy in the pathologic condition of the hypo- 

 physis as there is in an enlargement of the heart, thyroid gland, or the sella 

 turcica. 



3. Acromegaly does not depend, at least not solely, upon abolition of any 

 function of the hypophysis. 



4. A relationship between the thyroid gland and the hypophysis has been 

 already proved. 



5. It is not at all improbable that proliferation of the histological elements of 

 the hypophysis may be instituted in some cases by a primary enlargement of the 

 sella turcica ; in other cases, an oedema or haemorrhage ex vacuo. 



6. We have no reason for supposing that enlargement of the sella turcica 

 may not be as constant an occurrence in acromegaly as the changes in other 

 bones, or that it might not take place from similar cause or causes. 



R. M. p. 



Schenck. On Refractory Subcutaneous Ab- Schenck has isolated and Studied a 



scesses Caused by a Fungus Possibly Related fungus pathogenic for man. The 



to the Sporotricha. Johns Hopkins Hosp. . . ^ . ^ . 



Bull. No. 93, 1898. primary pomt of mfection was on the 



index finger, whence it extended up 

 the radial, side of the arm, following the lymph channels, and giving 

 rise to several circumscribed indurations, which were in part broken down and 

 ulcerated. Upon incising these areas, a quantity of gelatinous material was 

 found from which he obtained the micro-organism in pure culture. It grew well 

 on the ordinary media. Cover-slip preparations from agar and bouillon cultures 

 showed two forms : (1) a thread-like branching form, or mycelium, and (2) oval, 

 spore-like forms, or conidia. 



The relation which the conidia bore to the mycelium was determined by ob- 

 serving their develo'pment in hanging drops of alkaline beef broth, which were 

 placed under a moist bell-jar for forty-eight hours. The spores were quite com- 

 monly found, to the number of six or more, clustered to the tips of the spore- 



