368 True and Hunkel. The Poisonous Effect Exerted etc. 



Table XXXJV. 



Para-nitrophenol + 1 Na OH. 

 Begun Feb. 4, 4 : 00 P. M. 



Gram-mol. per liter. Length Feb. 4. Length Feb. 5. 



2 : 00 P. M. Condition. 



1/3200 15,0 mm 14,0 mm Dead. 



15,0 ., 14,5 „ 



14,5 ., 14,5 „ 



16,0 „ 15,5 „ 



1/6400 15,5 ., 22,0 „ Alive. 



16,0 ,, 20,5 



18,0 ., 27,0 



77 



77 77 



15,0 „ — Dead. 



Table XXXV. 

 Electrical Conductivity of Para-nitrophenol (Bader). 

 V. 



35,5 



71,2 

 142,4 

 284,8 

 569,6 



^^00 = 355 



From B a d e r ' s tables we can calculate the degree of disso- 

 ciation of ortho-nitrophenol to be 2,9 per cent at 2000 liters; 

 1,43 per cent at 500 liters. The para Compound dissociates 0,9 

 per cent at 569,6 liters. At the dilution first permitting the 

 lupines to survive, dissociation would seem to have advanced to 

 some considerable extent, judging by the marked reduction of 

 the loxic action in adding Na OH. The sum of the action of 

 the anions and of the nndissociated molecules seems, however to 

 be still a streng tactor in determining the loxic value oi tliis 

 Compound. 



The para Compound seems to owe its effectiveness chieflj to 

 the nndissociated molecules. This is indicated by the absence of 

 difference between the toxic values of the Compound itself and of 

 its Na Compound. It schould be pointed out, however, in this 

 connection that the comparatively small difference between the 

 results obtained with these two isomers by Bader seems to indi- 

 cate that the explanation may be hardly sufficient to account for 

 the difference in physiological action noted. 



Unfortunately, meta-nitrophenol was not available at the time 

 these experiments were performed. This as well as reasons 

 already suggested make a further study of the action of these 

 isomers desirable. 



It seems, however, clear that the introduction of a nitro 

 group (NO2) here increases to a marked degree the toxic value. 



(To be conclud.) 



