2J9 



the only regions where the nodules nia\' ])e found. 

 The mesenteric glands and the walls of the intestines 

 frequently shew them. And since extravasations of 

 blood may occur anywhere when the bacilli have 

 succeeded in passing beyond the abdominal circula- 

 tion into that of the general system it follows that the 

 nodules can be found anywhere also. The mouth, 

 throat, and the root of the tongue are favourite situ- 

 ations in even acute cases, and where the bird has 

 lived long enough I have seen them in all stages of 

 formation in the loose cellular tissues of the neck, 

 scalp, and face, (particularly near the angle of the 

 jaw), in muscles, in joints, in the lungs, and even in 

 bone and skin. 



One prominent characteristic of the disease is 

 the rapidit}' with which the nodules are formed. In 

 acute epidemics, such as often occur among Canaries 

 at the end of the breeding season when the virulence 

 of the microbe has been accentuated b}^ egg food, it is 

 often possible to determine the date of infection, and 

 the spleen has often been found greatly enlarged and 

 full of the seed-like nodules within as short a time as 

 two days after the first symptoms of illness have 

 appeared. The liver also, and even the throat in 

 some cases, often exhibits the same nodulated con- 

 dition at a very earl}^ date. Such cases are invariabl)'' 

 plump and well nourished, sometimes indeed very fat'. 

 They have not had time to become thin : the poison 

 has killed them before their tissues have become 

 oxidized and wasted in conneclion with the abnorm- 

 ally high temperature which always obtains in acute 

 affections. 



Another characteristic phenomenon is the persist- 

 ency of tlie caseation in those birds which drift into 

 the condition of chronicity, and even in those which 

 have recovered from the disease. T/ie nodules never 

 break down to become purulent cavities such as 7ve 



