CONTENTS 



X PROLIFERATIVE DISEASES OF THE 

 RETICULAR TISSUE AND MESENCHYMAL 



CELLS page 165 



1 Somatic mutation 165 



2 General considerations 168 



3 Experimental leukaemia 170 



4 Human leukaemia 1 75 

 {a) Chronic myeloid leukaemia 1 75 

 {b) Chronic lymphatic leukaemia 177 



5 Hodgkin's disease 180 



6 Multiple myeloma 180 



XI CLONAL SELECTION AND NEOPLASTIC 

 DISEASE 185 



1 The turnover of cells in various parts 



of the body 186 



2 The age incidence of cancer 1 88 



3 The control of cell relations 193 



4 Mutagenic and carcinogenic agents 196 



5 Conclusion 200 



Vlll 



