CONTENTS 



IV THE CLONAL SELECTION THEORY OF 



ANTIBODY PRODUCTION P^g^ 49 



1 The side-chain theory of Ehrlich 49 



2 Haurowitz-PauHng (direct template) 



theory 50 



3 Burnet-Fenner indirect template theory 51 



4 Jerne's natural selection theory 52 



5 Clonal selection theory 53 

 {a) Developmental considerations 56 



6 Comparison of theories 61 



7 Cellular reactivity required by a clonal 

 selection theory 64 



8 Summary 67 



V IMPLICATIONS OF THE CLONAL 



SELECTION HYPOTHESIS 69 



1 The secondary response and cognate 

 phenomena 70 



2 Anamnestic responses 72 



3 Action of adjuvants 80 



4 Local immunity 83 



VI IMMUNOLOGICAL TOLERANCE AND 



RELATED PHENOMENA 87 



1 Homograft immunity and tolerance 87 



2 Tolerance to antigens not associated 

 with implantation of genetically 



foreign cells 90 



3 Natural antibodies 95 



4 T agglutinin as a model of a natural 

 antibody 96 



vi 



