PROLIFERATIVE DISEASES 



The Bence-Jones (urinary) protein is of only secondary 

 importance from our point of view, although it seems likely 

 to provide clues of importance to the understanding of pro- 

 tein synthesis in the cell. From isotope studies, Putnam and 

 Hardy (1955) conclude that the urinary protein is not a 

 breakdown product of the abnormal circulating globulin 

 but that its behaviour is compatible with its being a pre- 

 cursor or abortive product of serum globulin synthesis. It is 

 of much smaller molecular size and is excreted by the kidney 

 almost immediately it is formed. But it resembles the serum 

 globulin in general amino-acid constitution and its antigenic 

 character ; each, however, showing individual differences from 

 one patient to another. 



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