INDEX 



Adaptive changes, 5, 14 



and analogy with mesenchymal- 

 cell change, 27 



and 0-D change, 17 



in virus populations, 4-23 

 Adaptive enzyme, 4 



and 'indirect template' theory of 

 antibody production, 55 

 Addison's disease, 170 

 Adjuvants 



as antigen depot, 80 



proliferative effect on clones, 82 

 Agammaglobulinaemia, 42, 47, 95, 

 141 



congenital, 42 



and hypersensitivity, 42 



and immune response, 143 



virus diseases in, 142 

 Agglutinin 



cold, 97 



iso-, 39, 43, 57, 95 



T, 39j 95-9 



see also natural antibody 

 Allergic diseases, 121 

 Amino acids, of abnormal globulins, 



181 

 Amniotic cavity, 16 



limit dilution passage, 18 

 Amyloid disease, 134 

 Anaemia, haemolytic, 43 



acquired, 126 

 Anamnestic response, 72, 74, 77 



cellular basis of, 119 

 Anaphylaxis, and stimulation of clone 



by antigen, 64 

 Anopheles (annulipes), in myxo- 

 matosis, 25 

 Antibody, 5, 13, 30, 35, 38-40, 44, 45, 

 47, 50-4, 57-9> 61-7, 69, 70, 

 72-109, 122-9, 132-43, 146-8, 

 178, i8g, 183 

 acute production of, 103 

 against tumours, 193 

 auto-, 35, 123, 126 

 cell-borne, 107, 125 

 classical circulating, 30, 36, 38-9 

 cold, 126 



effect of irradiation on production 

 of, 89 



fluorescent, staining detection of, 44, 

 109 



hay-fever type, 37, 39 



natural, 53, 95, 99 



nature of, 30 



production and X-rays, 100 



production in old age, 1 79 



see also Agglutinins, Mesenchymal 

 cells 

 Antigens, 30-2, 34-40, 49-52, 54, 59, 

 61-9, 72-9, 80-2, 86, 88, 90-6, 

 101-7, 113, 117, 123-7, 131-8, 

 146-8, 152-8, 162, 179 



auto-, thyroglobulin, 124 



bacterial, 101 



and clonal selection theory, 49-67 



diminishing response to, 1 79 



as identity marker, 195 



nucleoprotein, 79, 88 



primary response, 31 



secondary response, 31 



tolerance to, 92, loi 



see also Antibody, Immunity, Mesen- 

 chymal cells 

 Antigenic determinants, 30, 36, 49, 51, 



61, 71, 73, 78, 146 



reacting with forbidden clones, 1 59 

 Antigenicity, 36 



transfer of, 132 

 Appendix 



and antibody production, 100 



lymphoid tissue in, 83, 101 

 ARBOR viruses, 77 

 Arthritis, in agammaglobulinaemia, 



144-5 

 Arthus reaction, 103 

 Autoantibody, 35, 126 

 Autoantigen, thyroglobulin, 124 

 Auto-immune complement fixation 



test, 137 

 Auxotrophs, 8 



y5-galactosidase, 4, 13, 71 

 Bacterial antigens, 101 

 Bacterial papillae, 7 



203 



