INDEX 



Bacteriophage, as antigen, 32 

 Bence-Jones protein, 184 

 Blood group 



Bombay anomaly, 58 



chimera, 58 

 Bone marrow, 89 



Caffeine, as bacterial mutagen, 199 

 Cancer 



age-incidence of, 188 



log-log relationship in, 190 



somatic mutation theory of, 165 

 Carcinogenesis, chemical, 195 

 Carcinoma, in merino sheep, 167 

 Chick embryo 



amniotic inoculation of, 16 



viral infection of, 22 

 Chimeras, 58, 87 



X-ray, 1 1 8 

 Clonal selection theory, 53 



and absence of normal homeostasis, 



157 

 and cancer, 149, 186 

 cellular basis of, 118 

 development of abnormal serum 



proteins, 127 

 diminishing response to antigens, 



179 



dominance of best adapted clone, 25 



effect of adjuvants on cell prolifera- 

 tion, 80 



elimination of antibody-producing 

 clones by irradiation, 89 



eosinophils, 1 1 8 



evolution of forbidden clones, 124 



fixation of reactant lymphocyte, 84 



homeostatic mechanism, 130 



homograft immunity, 89 



immunology, 69 



importance of lymphocytes in im- 

 mune response, 100 



inhibition of forbidden mutation, 

 145, 148 



interpretation of agammaglobu- 

 linaemia, 143 



justification of, 69 



mechanism of clonal selection, 75 



multiplication of lymphoid tissue, 

 144 



and natural antibodies, 95 



number and rate of proliferation of 

 cells, 104 



pathology of the immune response, 



122 

 predication of active (antigen- 



stimulable) sites of cells, 80 

 proliferation of stimulated mother 



cells, 126 

 somatic mutation of clones, 1 22 

 special function of lymphocyte in, 



"9 

 at subcellular level, 105 

 and tolerance to antigens, 92 

 and tolerance to bacterial antigens, 



101 

 see also Immune responses. Mesen- 

 chymal cells 

 Clones 



clonal phenomena in bacteria and 



viruses, 4 

 forbidden, 136 



forbidden patterns, 122, 145, 157 

 forbidden, reacting with antigenic 



determinants, 159 

 of globulin-producing cells, 54 

 mutant, reaction of, 140 

 Collagen diseases, 131, 132 

 Complementary configurations of cell 



and antigen, 31 

 Complementary relationship, 67 

 Conditioned neoplasm, 169, 173, 193 

 Contact dermatitis, 41 

 Contact inhibition in tissue culture, 1 94 

 Control 



morphogenetic, 193 

 proximity, 194 



see also homeostatic mechanism 

 Corneal transplantation, 35 

 Cortisone, in acute lymphatic leu- 

 kaemia, 170 

 Critical point of Medawar, 60 



Davenport's phenomenon, 74 

 Denaturation of antibody, 54 

 Diaminopimelic acid, 161 

 Differentiation 



embryonic, 56 



phase of, 60 

 Diphtheria toxoid, 37 

 Direct template theory, 50 

 Disseminated lupus erythematosus 



(DLE), 136-9 

 Distemper, canine, 156 

 DNA nucleoprotein, 79, 112 



204 



