INDEX 



Ionizing radiation, 196 



in production of leukaemia, 1 75 

 /joagglutinins, 39, 43, 57, 95 



Japanese B virus vaccine, 1 79 



Kaposi's eruption, 151 



L.E. cell test, 136, 139 

 Letterer-Siwe disease, 135 

 Leukaemia 



acute sarcoma-cell, 1 79 



age incidence of, 1 79 ; in childhood, 

 198 



from atomic-bomb radiation, 197 



experimental, 170 



granulocytic, 176-7 



induction by virus of, 171 



induction by X-rays of, 197 



ionizing radiation in, 1 75 



lymphatic, 128; abnormal globu- 

 lins in, 1 79 ; antibody production 

 in, 178; chronic, 1 69 ; haemolytic 

 anaemia in, 1 78; use of cortisone, 

 170 



mouse, 170-4 



myeloblastic crisis, 1 75 



myeloid, 175-7, ^97 



production by ionizing radiation, 1 75 



recent increase in, 197 



relation of thymus, 1 7 1 



and response to antigens, 1 79 



statistics of, 198 



X-radiation in pregnancy, 197 



in X-rayed mice, 172 

 Limit dilution passage, 21 



in amniotic cavity, 18 

 Lupus erythematosus, disseminated 



(DLE), 136-9 

 Lymphatic leukaemia, see Leukaemia 

 Lymph node cells, in cellular transfer 



of immunological reactivity, 45 

 Lymphocyte, 54 



as antibody producer, 44 



as carrier of nucleic acids, 1 1 2 



destruction by X-rays, loi 



fixation of reactant, 84 



functions of, 118 



in immune response, 44 



liberation of antibody by, 1 09 



life history of, 55 



mobility and transformation of, 119 



role in immunity, 107 



survival time of, 1 74-5 



tissue infiltration of, 132 



transfer of DNA amongst, 1 74 



transformation, iii, 114 

 Lymphocytosis, stimulating factor, 



170 

 Lymphoid tissue, 83 



relation to virus disease, 143 

 Lymphoma, follicular, 1 69, 1 78 



Macroglobulin, 126 

 MacroglobuHnaemia, 137, 141 

 Macrophages, 82, 115 



and secondary antigen, 33 

 Mammary gland, plasma cells in, 84 

 Mast cells, 64 

 Maturation of cells, 94 

 Measles, 153-6 



giant cells in, 144 



pathogenesis of, 154 



pneumonia, giant-cell, 154 

 Medawar, critical point of, 60 

 Mesenchymal cells 



acquired haemolytic anaemias, 1 26 



adjuvants, 82 



anamnestic response of, 79 



antibody-producing, 56 



clonal selection theory, 49, 58, 64, 

 67, 118, 200 



collagen diseases, 131, 134-6 



differentiation during embryonic 

 life, 56, 60, 200 



eosinophils, no, 117 



forbidden patterns of, 128, 135, see 

 clones 



function in immunity, 29, 107-20 



genetic characteristics, 158 



granulocyte, no 



haematoblast, 1 1 o 



Hashimoto's disease, 124 



Hodgkin's disease, 168, 180 



and immunological tolerance, 100, 

 103 



immunologically reactive sites of, 



54 

 interrelation of forms of, 1 10-16 

 and leukaemia, 1 75 

 liberation of pharmacologically 



active agents, 64 

 and lupoid hepatitis, 125 

 lymphoid-macrophage system, 1 1 5 



206 



