INDEX 



Mesenchymal cells {cont.) 



modification by virus infection, 1 23 

 multiple change to stem cell macro- 

 phage, lymphocyte and plasma 

 cell when stimulated, 1 18 

 mutation, and selective survival, 27, 

 127, 128; to malignant form, 124 

 and neoplastic disease, 185 

 non-antibody-producing stage of, 



96 

 and pathology of immune response, 



123-8 

 population genetics of, 200 

 physiological and mutational 



change, 56 

 proliferation when stimulated, 69, 



118 

 and proliferative diseases, 165-8, 



174-7 



and protein synthesis, 184 



reticules, 1 1 1 



and sarcoidosis, 161 



self-replicating phenomena of, 79 



sensitivity to tuberculin, 41 



and spleen, 103 



stimulation of, by antigenic deter- 

 minant, 67 



and transduction of DNA, 1 74 



see also Homeostatic mechanism, 

 Lymphocyte, Proliferation of 

 cells 

 Mesenchymal cell system, charac- 

 teristics of, 15 

 Mesenchymal reserves, 46 

 Metalophil cells, 115 

 Migration of neural crest cells, 1 94 

 Mosquitoes, transmission of myxo- 

 matosis by, 25 

 Multiple myeloma, 180 

 Mutagen, caffeine, 199 

 Mutagenic action, 196 

 Mutagenic agents, 8 



caffeine, 199 



streptococcal, 133 

 Mutant clones, reactions of, 140 

 Mutations, 6, 21, 27 



antibiotic-resistant strains, 7 



bacteriophage-resistant, 7 



and cancer, 195 



definition of, 165 



during segmentation, 1 66 



and haemolytic anaemia, 132 



histidine-independent, 7 



malignant, 139 



nutritionally deficient, 7 



0-D change, 1 7 



phenotypic expression of, 167 



prerequisite for clonal selection 

 theory, 200 



pseudo-, 12 



rarity of, 1 1 



regulation of, 145; see homeostatic 

 mechanism 



rough E. coli, 9 



sequential, 191 



in skin epidermis, 187 



somatic, 55, 63, 67, 80, 127 



somatic theory of cancer, 165 



and tumours, 195 

 My colic acid, 161 

 Myelomatosis 



a conditioned neoplasm, 182 



multiple, 147, 177, 180 

 Myxomatosis 



in Australia, 23 



Australian field strain, 24 



in Europe, 26 



French strain, 27 



natural infection, 1 1 



transmission by mosquitoes, 25 

 Myxomatosis virus, 22 



virulence of (in Australia), 22-7 



Natural selection theory (Jerne's), 52 



Neoplasms, conditioned, 169, 173, 193 



Nephritis, acute, 157 



Neural crest cells, migration of, 194 



Neuraminidase, 98 



Non-reactivity of young animals, 93 



Nucleoprotein 



antigens, 79, 88 



DNA, 112 



0-D change, 15-19 



definition of, 17 

 Ophthalmia, sympathetic, 126 

 Ovalbumin as antigen, 40 



Paralysis, immune, 94 



Passive transfer, 37 



Penicillin 



effect on B. cereus, 4 



effect on sensitive bacteria, 8 



Periodic selection, 10, 12 



207 



