INDEX 



Permease, 13, 71 



Peyer's patches, 83 



Phase change in Sabnonellas, 10 



Phenotypic lag, 15 



Plasma cells 



in agammaglobulinaemia, 42 



antibody in, 109 



as antibody producers, 44 



in experimental influenza, 84 



function of, 70 



mature, 115 



origin of, 115 



proliferation of, 113 

 Plasma-cell tumours, 180 

 Platelet and antigenic determinant, 



129 

 Pneumonia 



atypical, 99, 123, 128 



giant-cell measles, 154 

 Poissonian distribution, 21 

 Polio viruses, 83 

 Population dynamics of mesenchymal 



cells, 81, 201 

 Population genetics, 9, 10, 12, 16 

 Prausnitz-Kuster phenomenon, 39 

 Primary immunization, 69 

 Primary response, 31 

 Proliferation of cells, 61-2, 77-8, 104- 

 5, 120, 1 30-1, 133-6, 140, 145-7, 

 153, 166-8, 175, 180, 185-7, 201 ; 

 see Mesenchymal cells 

 Properdin, 39, 99 

 Protoplasts, 162-3 

 Prototrophs, 7 

 Purpura 



sedormid, 129 



thrombocytopenic, 129 

 Pyrogenic response, 103 



Reticuloses, 169 

 Rheumatic fever, 156 



investigations on, 158 



predisposing causes, 158 

 Rheumatoid arthritis, 43, 131 

 Rose's test, 131 

 Runt disease, 88 



Salmonellas, phase change in, 10 

 Sarcoid, relation to tuberculosis, 160 

 Sarcoid nodule, 130 

 Sarcoidosis, 160-3 



Kveim test, 160 

 Secondary response, 31, 70 

 Sedormid purpura, 129 

 Selection, periodic, 10, 12 

 Selective survival, 27 



of virus particles, 22 

 'Self' and 'not-self 



components, 34, 46, 59 



information problem, 36, 47 



recognition, 59 



self-markers, 51 



self substance, 34 

 Self-antigens, lack of response to, 1 38 

 Sheep, fleece mosaics in, 166 

 Shwartzman phenomenon, 103 

 Skin epidermis, mutation in, 187 

 Somatic mutations, see Mutations 

 Staphylococcal toxoid, 32 

 Stem cell, 46 



Streptococcal infections, 147, 156-9 

 Streptococci 



haemolytic, 156 



nephritogenic, 133 

 Subcellular units, selection amongst, 



105 

 Sympathetic ophthalmia, 1 26 



Randomization, 60 



of pattern, 66 

 Reactive site, 30, 65, 67 

 Reactivity of clone with antigen, 



32-7, 41, 53, 91-3, 163 

 Recognition mechanism, 62 

 Replica method, Lederberg's, 8 

 Response 



primary, 31 



pyrogenic, 103 



secondary, 31, 70 



varieties of immune, 92 

 Reticular cell, primitive, 1 1 1 , 119 



T agglutinin, 39, 95-9 

 Template theory 



direct, 50 



indirect, 51, 55, 62 

 Thoracic duct lymph, 45, 109, 114 

 Thrombocytopenia, 136 

 Thymus, relation to leukaemia, 171 

 Thyroglobulin, 34 



as autoantigen, 124 

 Tissue culture, 69 



Tolerance, 34-5, 50-1, 58, 61, 65, 

 87-8, 90-102 



development of, 60 



208 



