74 Physiology of the Kidney 



The urine flow (V) increased transiently from slightly above 

 1 cc. to above 8 cc. per minute; whether this diuresis is at- 

 tributable to local action of the oil of juniper upon the renal 

 tubules, or to a reduction in the secretion of the antidiuretic 

 hormone of the posterior pituitary gland in consequence of 

 reflex excitation from the gastro-intestinal tract, is undeter- 

 mined, though the latter seems the more likely explanation. 

 The phenomenon of diuresis is, however, of secondary im- 

 portance; changes in urine flow represent merely slight 

 changes in the reabsorption of water from the glomerular 

 filtrate, and since such changes can be elicited by many dif- 

 ferent types of stimuli acting through the supraoptic-hypo- 

 physeal mechanism, they have little fundamental significance 

 with regard to renal function. What we were looking for 



limjjiiJiiJiijjir jjJiJiiuTnrr miiiiiiiiiiiuiiiii TT 



700- 

 500- 



200- 

 150 



,N 1 I Lxiiiiiiixiiiiiii.. i jmiii[, 



0.25- 

 f?).20 



0.15 



■imiliir'^^TTnmTnmmiP^ 



140- 

 120- 

 100- 



rrTtTTTTTTTfTTTr i 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ii i ii 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 m i 



'^ 1.0 cc. OIL JUNIPER IN 60 cc. 25 PER CENT ALCOHOL PER OS 

 JjiJi>'-MJJ.I H I I 1 1 1 1 II II I II 1 1 1 1 1 1 1 IJim 



"20- 



FIGURE 1 



Figure 1. Action of oil of juniper on effective renal plasma flow, (D^diodrast clear- 

 ance in cc. per minute), filtration rate (INzrinulin clearance in cc. per minute), filtra- 

 tion fraction (FFrrinulin/diodrast clearance ratio), blood pressure (BP in mm. Hg) and 

 urine flow (V in cc, per minute). (From 6). 



