1^ 



Physiology of the Kidney 



Were I to tax your patience by showing a fair sample of 

 our negative experiments, such as the one given in Figure 1, 

 you would be prepared to believe, as indeed we at times have 

 been tempted to believe, that the renal circulation and the 

 glomerular apparatus are so constructed as to be incapable of 

 variation. So I pass immediately to the demonstration that 



I000-. 

 700- 



500- 



400[- 



350- 



300- 300J- 



250- 



200h 



G-Tm 



0.20- 



220|-°''^- 

 200- 



180- 



160- 



140- 



120- 



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eo- 



60- 



H iumuiimuiillllllllll 



mTTiTTTTTrrirrrrr 



-iimiiiiiii 



0.5 MGM. ADRENALIN IM. xn c K;,r k>, ahdc m ik/, 

 0.5 MGM. ADRENALI N SUBCU.T?;?, l^^^\ ^?^,^!1] , m 



FIGURE 2 



Figure 2. Action of adrenin on effective renal plasma flow, etc. Legend as in 

 Figure 1. G-Tmuz: maximal rate of tubular reabsorption of glucose under conditions 

 of tubular saturation, in mgm. per minute. G-Tm is measure of the number of active 

 glomeruli in the kidney. 



the renal circulation can be profoundly altered, and I have 

 selected for this demonstration the action of that dynamic 

 hormone, adrenin (Figure 2). The subject of this experi- 

 ment showed in four control periods an average renal plasma 

 flow of 926 cc. per minute. Adrenin (0.5 mgm, intramuscu- 

 larly and 0.5 mgm. subcutaneously) reduced the plasma flow 

 to a minimum of 510 cc. (i.e., to 5 5 per cent of the control 



