The Renal Blood Flow 



79 



Had adrenin closed any glomeruli by its vasoconstrictor ac- 

 tion, this figure would necessarily have been reduced, regard- 

 less of any changes in the filtration rate in the remaining 

 active nephrons. The failure of glucose-Tm to decrease 

 shows that adrenin in this dose (which is about the maximal 

 dose which may be administered to man without serious dis- 

 turbance) did not close any glomeruli. 



We have examined a number of so-called sympaticomi- 

 metic drugs, but the only other one of immediate interest is 



3001- 

 0.25- 

 0.20- 200f- 



0.15-- 



Tiniiiif 



mmtiiUIIIIIIIIIlf 



-iTTTTTTrTTTTrTTTTrrr 



^JiiliiLLliiiiiiillLUiUU iiuuuiiiuuLUiiuiLLumLiiUuuuLiT mrrnT 



IN_ 



"I 1 — '^""'•'•'•^nrrrTri irrrrnTrrrri 1 rrTTrTTTTT.iiim 



12.2 10.7 9.1 



35 MGM. EPHEDRINE SULPHATE INTRAVENOUSLY 

 5.1 5.1 5.4 5.7 5.3 5.3 5.4 



-65 MINUTES 



FIGURE 3 



Tfe- 



ii^ 



U 



Figure 3. Action of ephedrine on efiFective renal plasma flow, etc. Legend as in 

 Figure 1. 



ephedrine (Figure 3) . The net effect of this drug in man is, 

 like that of adrenin, vasodilatation, as evidenced by a de- 

 crease in the total peripheral resistance.^^ We have been 

 rather surprised to find that ephedrine in therapeutic doses 

 has no or negligible effect upon the renal circulation, sug- 



