88 



Physiology of the Kidney 



1500 



1000 



700 



500- 500 

 400-^ 



300- 300- 

 200 



70- 



60 -^ 



50- 



40- 0.20 



G-Tm 



0-Tk 



0.15 

 0.10 



> ITHTTTTTTTTT 



''|lllllllliilJL.. 



"Iiiniiiiiiii 



ADRENIN 



--pww*WBi 



TTTTrTTTTTTr 



BASAL 



rnmiiiiTii 



TTTTTTTTrTrr 



'- iTTTrrrrrrTrr 



...iiiimi.ii 



FIGURE 6 



Figure 6. Method of examination of action of adrenin and hyperemia on renal func- 

 tion. Legend as in previous figures, except D-Tm, which indicates diodrast-Tm in mgm. 

 of iodine per minute. D-Tm is the maximal rate of tubular excretion of diodrast under 

 conditions of tubular saturation, and is a measure of the number of active, normal 

 tubules in the kidney. Since the extraction ratio of diodrast is reduced during the mea- 

 surement of D-Tm, the diodrast clearance (D) is no longer a measure of renal plasma 

 flow, and this value, as well as the filtration fraction (FF) must be interpolated from the 

 control observations at the left of each section. 



the observation of diodrast and inulin clearances, and for glu- 

 cose-Tm. After four clearance periods, the plasma diodrast 

 level was raised to 40-60 mgm. per cent of diodrast iodine, 

 and diodrast-Tm was measured during 5 clearance periods. 

 The interval separating these two groups of observations need 

 be no longer than 20 minutes, and the renal plasma flow as 

 observed during the first half of the experiment may be as- 

 sumed to indicate the plasma flow when diodrast-Tm is being 

 measured. 



