Swine Plague. 495 



and died about an hour later. The virus was found in its blood and 

 organs. 



A guinea-pig inoculated at same time with a large quantity of 

 the juice from the same source, died in about 14 hours after 

 inoculation. The virus was found in its blood and organs. 



A guinea-pig and pigeon were inoculated with small quantities of 

 virus derived fi'om the mesenteric glands of a pig dead of the disease. 

 The guinea-pig died 5 days after inoculation, and examination 

 revealed abscess at seat of inoculation, patchy croupous pneumonia of 

 lungs with adhesions to chest walls, enlarged liver and spleen, and 

 inflammation of brain and intestines. The lymphoid tissues (Fevers 

 patches and solitary glands) of the ileum, and lymphoid tissues of 

 the ctecum and large intestines, were the principal seats of the 

 intlammation. The guinea-pig was very sick 24 hours after inocula- 

 tion, its temperature rose to 104'5 deg. 48 hours after inoculation, and 

 was 103 deg. on the morning of the day on which it died. The pigeon 

 died 29 days after inoculation and was ailing the whole time. The 

 lungs which were adherent to the chest w<dl, were very friable and 

 showed old pneumonic patches. The liver was soft and enlarged, the 

 intestines were inflamed, and here and there at the seat of the 

 lymphoid tissues ulcers were observed. The pectoral muscles in 

 which the inoculation was made were very friable. The virus was 

 found in the blood and orgaiis of both guinea-pig and j)igeon. 



Ou 31st March, a guinea-pig was inoculated with an agar culture 

 from the spleen of a. guinea-pig that died five days after inoculation 

 with virus from a swine plague pig. Two days after, its temperature 

 rose to 103 deg. and it was very sick. On the third day its temperature 

 rose to 104 deg. and then it ran along or above 103 deg. till 

 15th April, when it sank to 102 deg. It then ran somewhere along 

 the line of 102 deg. till the 23rd, when it rose to 102'4 deg. It sank 

 again and then gradually rose till at noon on 29th it was 104 deg. 

 There would seem to have been a recrudescence in this case. From 

 25th to 29th the temperature gradually rose and then gradually 

 .declined till 1st May, and on 2nd May it made a sudden droj) to 

 98 deg., and from this time onward, the animal got rapidly well. The 

 virus was observed in the blood. 



A guinea-pig inoculnted on 17tli April with a gelatine growth 

 of the bacillus that had ])assed through several generations of culture, 

 after a few days' illness, recovered. Evidently, repeated culture had 

 attenuated the virulence of the germ. 



On 4th April a guinea-pig was inoculated with blood from the ear 

 of an experimental pig, and after a short illness it recovered. 



Ou April 29th two guinea-pigs were inoculated with agar cultures 

 from tubes of repeated cultivation. Both became ill. On 8th May one 

 was killed for examination. Intestines were found inflamed, the 

 lungs were normal, and an abscess existed in Hank at seat of inocula- 

 tion. The other guinea-pig eventually recovered. On the same date 



