June 3, 1918 



Destruction of Tetanus Antitoxin 



489 



Table VII. — Comparison of antitoxin destroyed with protein digested 

 EXPERIMENTS 3-6.1 : TRYPTIC DIGESTION 



Exper- 

 iment 

 No. 



3- I 



5- I 



6.1 



Antitoxin No. 



420 F. 

 420 F. 



Serum 374. 

 Serum 374. 

 Serum 374. 



Antitoxin X . 



Antitoxin X . 



Toxin 



No. 



F4 

 F4 



F4 

 F4 

 F4 



F4 



Digestion 

 period on 

 day of in- 

 oculation. 



Days. 



76 



45 



Mix- 

 ture. 



a A 

 B 

 C 

 D 

 A 

 B 

 C 

 D 



A 

 B 

 C 

 D 

 A 

 B 

 C 

 D 

 A 

 B 

 C 

 D 



A 

 B 

 C 

 D 

 A 

 B 

 C 

 D 



Antitoxin 

 destroyed. 



Per cent. 

 O 

 87 



75 



87 



o 



over 95 



75-87 

 over 95 



o 

 65 

 65 

 65 



o 



91 



82 



82 



o 



96 



82-91 

 82-91 



o 



82 



o 



82 



o 



82-93 



o 



82-93 



Coagulable 

 protein di- 

 gested past 

 coagulable 

 stage. 



Per cent. 



O 



4 



57 



65 



56 

 58 

 o 

 o 

 80 

 78 



o 



77 

 o 



77 



Amino 

 nitrogen 

 liberated 



digestion. 



Per cent. 



40 

 37 



O 



o 

 53 

 31 



57 

 35 



71 



o 



70 



EXPERIMENTS 20-22 : PEPTIC DIGESTION 



420F. 



420F. 



Serum 268. 



F4 



Fi 



a g 



96 



95 



o 



2 

 6 



95 



o 

 o 

 o 



17 



o 



4 



5 



18 



"In these mixtures A contained only antitoxin; in addition to this the others contained: B, sodium 

 carbonate; C, trypsin; D, sodium carbonate and trypsin. 



t* See page 481. 



« In these mixtures A contained only antitoxin; in addition to this the others contained: B, hydrochloric 

 add; C, pepsin; D, (>epsin and hydrodbJoric add. 



* See page 481. 



