1886.] on Becent Progress in the Goal-tar Industry. 461 



panied by no drawbacks. It occurs in commerce in the free state. 

 The production of antipyrine, in spite of these valuable qualities, is as 

 yet small, its chief employment being in Germany, where it has been 

 successfully used in cases of typhoid epidemic. The price is 6s. per 

 pound. 



The following equations explain the formation and constitution of 

 this interesting body. The foregoing febrifuges are manufactured at 

 Hochst under the superintendence of Dr. Pauli, to whose kindness the 

 speaker is indebted for an interesting series of specimens illustrative 

 of the manufacture of antipyrine. 



CH3.CO.CH2.CO2C2H. + CeHj.NH.NH. 



Acetoacetic ether Phenylhydrazine 



= H2O + C0H5.OH + Cio H10N2O 



Tyrazol 



CioH.oN^O + ICH3 = IH.CioH,(CH3)N20 



Antipyrine-liydriodide 



Dr. Knorr formulates pyrazol thus : 



CgH^ C CII3 



CO CH2 



And antipyrine is 



N N CH, 



./ V 



co- 



The antipyretic effect of this compound is strikingly shown in the 

 following temperature readings in a case of typhoid kindly com- 

 municated to the speaker by his friend Dr. Dreschfeld of Manchester. 

 Each of the second set of readings was made two hours after a dose 

 of 30 grains of antipyrine had been administered. 



I. II. Diff. 



Tlialline. — The third of the artificial febrifuges is thalUney which is 

 offered as the tartrate and sulphate. It is manufactured by the Badische 

 Company. Thalline is said to be used as an antidote for yellow 

 fever. Its scientific name is tetrahydroparaquinanisol, and it was first 



