128 



EMiL VON SKRAMLIiC 



Sometimes there are certain deviations from the former sequence. 

 Cycloform for example, often affects the salty substrate more than the 

 bitter. The sweet substrate is more susceptible to Alypin than the sour 

 substrate. The Tropacocain susceptibility sequence is 



bitter > sweet > salty > sour 



Subcutin and Anaestheform had a very strong effect on all substrates, taste 

 subject I. The bitter substrate, however, as always the most susceptible. 

 Thus, 1 min after Subcutin no threshold for quinine could be obtained ; 

 the threshold incr.iased 50 times for NaCl, 35 for tartaric acid and 15 for 

 cane sugar. 



Also those anaesthetics which were used in a ten times lower concen- 

 tration because of their low solubility had varying effects on the different 

 substrates. Particularly effective were Acoin and Eucupin (Table 2). 

 There was no quinine threshold to be found 10 min after Acoin application 

 and 1 min after Eucupin the quinine threshold was more than a 

 hundred times increased, and even after 10 min it was about 11 times 

 normal. 



Table 2. Proportional increase of gustatory thresholds / min after exposure 



TO 0.03 M anaesthetic solutions, a dash — INDICATES THAT NO THRESHOLD COULD BE 

 FOUND DUE TO THE POWERFUL EFFECT OF THE ANAESTHETIC. 



The salty substrate is also very susceptible. Eucupin and Diocain had a 

 very marked influence, increasing the 1 min sodium chloride threshold to 



