366 



B. ANDHRSSON AND OTHERS 



develops (Fig. 8), The " heat loss centre " thus seems to inhibit the appa- 

 rently humoral mechanism responsible for the hypothermic hyperglycemia. 

 Further studies may reveal to what extent the pituitary-adrenal system and 

 the adrenal medulla may be involved in the development of this hyper- 

 glycemia. 



AVS 



Fig. 4. Two examples of persistent hyperthermia evoked by central cooling in 

 the same goat. Central cooling produced within two hours a rise in rectal 

 temperature to 40.3 to 40.5°C ; a further rise occurred 8 to 12 hr later. On 

 termination of a 3-day cooling period, rectal temperature remained elevated for 

 one day ; in contrast, following a 7-day cooling period, the core temperature 

 did not reach normal level for 3 days. (From Andersson, Gale, and Sundsten, 



1962a.) 



INFLUENCE OF HYPOTHALAMIC TEMPERATURE ON 

 FOOD AND WATER INTAKE 



During the studies of central regulation of body temperature in the goat 

 attention has also been paid to the food and water consumption of the 

 animals and to their alimentary behaviour. Certain observations have 

 been made which may perhaps be explained most easily in the light of 

 Brobecks' (1948, 1960) " thermostatic " theory concerning the regulation 

 of food intake. 



The importance of the hypothalamus for the regulation of food and 

 water intake has been demonstrated in several ways. A bilateral destruc- 

 tion of the ventromedial hypothalamus causes obesity (Hetherington and 



