Miscellaneous Papers. 315 



VII. STUDIES IN AN ANTITOXIN ELIXIR, OR CARRIER, FOR 



CALCIUM CYANAMIDE. 



Use of CaCNj in the Furthering of that Chemical Transformation, or Catalysis' 

 WHICH THE Tubercular Bacillus Fails, because of the Shortness of Its Life* 

 to Complete. 



An elixir which performs the functions of a carrier for cyana- 

 mide of lime, in the case of minimum doses, without salivation 

 effects, is the following: 



R.— Calcium glycerophosphate, 8 gr. 

 Sodium glycerophosphate, 16 gr. 

 Iron glycerophosphate, li gr. 

 Manganese glycerophosphate, 1 gr. 

 Quinine glycerophosphate J gr. 

 Aromatic elixir of cascara sagrada q.s. to make 1 pint. 

 Macerate in the above g^^ gr. of calcium cyanamide, pulv. 

 Sig. — Give 60 mm. three times daily, according to patient's needs, with 

 hypodermic. 



The foregoing elixir was used in the treatment of animals with 

 cyanamide of calcium. 



VIII. ACTION OF ELIXIR ON ANIMALS. 



Two dozen guinea pigs of the healthiest type inoculated for 

 a period of twenty-five to ninety days, in due course, with tu- 

 bercules; were given hypoderraically the foregoing formula for 

 first five days, also internally, the said elixir, and all are healthy 

 and to all appearances fat and well. 



Cows with tubercular bacilli were given, hypodermically, the 

 foregoing formula for the first five days; also internally. All are 

 healthy, and, to all appearances, fat and well, gaining each day. 

 The same is true of twelve infected Belgian hares infected to ter- 

 tiary stage, there not having been a single one of them that did not 

 recover fully in 171 days. 



IX. HOPES AND CONCLUSIONS BASED UPON THIS INVESTIGATION. 



We gather, therefore, from these studies — 



First: That there is a definite organic basis to the exudations 

 of the tubercular bacillus. 



Second: That this organic basis is an analogue to the base of 

 milk, known as casein. 



Third: That it is possible to attack in animals that are physio- 

 logically similar to man the artificially produced systemic phthisis 

 state (even after the subjects have reached the most direful patho- 

 logical condition, after inoculation with tubercules), with success. 



Fourth: That we have been in many cases more successful in 

 the combating of the artificially induced disease than in the propa- 

 gation of cultures of bacilli. 



