36 Kansas Academy of Science. 



lene-phenyl-isoxazolon. With dilute alkali these isoxazolon 

 derivatives dissolved and formed a salt from which the same isoxa- 

 zolon could be regained by adding hydrochloric acid. With heat 

 and standing, however, this breaks down, giving the amine and 

 another salt. 



When hydroxylainine acts on the amides of aminomethylene- 

 aceto or beuzoylacetic acids, there are formed 5-methyl or phenyl- 

 isoxazol 4-carboxylic acids. These isoxazols, under the influence 

 of alkalies, rearrange to form substituted amides of acetyl or ben- 

 zoylcyanacetic acid. To study these reactions several compounds 

 were made, including the following: the o-totylamid of 5-phenylis- 

 oxazol-4-carbocylic acid, and from this by the action of NaOH ben- 

 zoyl-cyanacet-o-toluid; p-tolylamide of 5-phenyli8oxazol-4-carbo- 

 xylic acid, and from this benzoyl-cyanacet-p-toluid; the p-anisylamid 

 of 5-phenylisoxazol-4-carboxylic acid which with the alkali gives 

 benzoylcyanacet-p-anisid; the anilid of 5-phenylisoxazol-4-carbo- 

 xylic acid, which likewise rearranges; also, the 0-totyl and p-totyl 

 amides of 5-methyli80xazol-4-carboxylic acid were made, giving in 

 the same way acetcyanaoeto-o-toluid and p-toluid. The anilid of 

 5-methylisoxazol-4-carboxylic acid was separated with difficulty, 

 but reacted in the same way to form acetcyanacetanilid. 



