Phji.^ical cnid Chemical Papos. 107 



obtained by formation of the platinum salt which is difficultly 

 soluble in water, or by treatment of the hydrochlorides with 

 alcohol. The hydrochloride of anhalonin is precipitated when 

 a solution, in absolute alcohol, of the alkaloids insoluble in ether 

 is neutralized with HCl. This principle is said to be strongly 

 poisonous and produces effects similar to those of strychnine. 

 Lophophorin remains in the mother liquor of the hydrochlo- 

 rides of the alkaloids insoluble in ether, from which it may be 

 separated. It has not been obtained in pure condition, but only 

 in the foi'm of a colorless syrup. 



PHYSIOLOGICAL TESTS. 



ISING THE ABOVE CONCENTRATED EXTRACTIVE MADE BY OURSELVES. 



The object of the investigation being only to determine the 

 toxicity of the drug and to locate its relationship to other 

 known poisons, it was only necessary to make a few experi- 

 ments upon the lower animals, such as frogs and guinea pigs. 



A solution was made of the concentrated extract represent- 

 ing the mixed poisonous products of the drug of the strength 

 of 8 mm. to the cc. This solution was sent over to the Phar- 

 macological Laboratory to Doctor S. A. Mathews, with a re- 

 (luest for a report upon the toxicity of the substances, and, if 

 possible, to get a report upon its relation, if any, to other 

 known poisons. Doctor Mathews reports that one-fourth of a 

 cubic centimeter, representing 2 mm. of this extractive, put a 

 frog into tetanus spasms almost immediately, and the action 

 upon the frog was practically identical with that of strych- 

 nine. 



One of the principles which has been isolated from this drug 

 and the structural formula for it are as follows: 



CH.j(NH) (CH;;) 1 

 OCH;: 3 

 Mescaline: Cr,H- OCH. 4 



OCH:: 5 



Our object will be, in the future, to obtain a large quantity 

 of the buttons and endeavor to separate its various constitu- 

 ents. 



