140 
REPORT OF TRAVELLING PATHOLOGIST AND PEOTOZOOLOGIST 
The drug in all cases except two (Nos. 7, 8) was injected under the skin of the back. 
The local effects of inoculation were practicallj' nil. In two (Nos. 7, 8) the rats were made to 
drink the drug, which is quite tasteless in solution. By giving no water to the animals for 
twenty-four hours the required quantity of solution was at once drunk when presented to them. 
The results were satisfactory, for the two rats thus treated were permanently cured. It would 
appear from these cases that the drug is just as potent when taken by the mouth as when 
administered subcutaneously. One rat (No. 9) was treated with Atoxyl subcutaneously, with a 
permanent cure as result. The rat employed in experiment No. 1 remained cured for four 
months. It was then re-inoculated, and became infected as other rats. Later it died of this 
infection. 
From the limited nature of the experiments it is impossible to pronounce very definitely on 
the results, or to compare the action with that of Atoxyl. If it be found that the administration 
by the mouth is as sure a method of giving the drug as subcutaneously, this will be a distinct 
advantage over Atoxyl. Colonel P. J. Lambkin, R.A.M.C., has recently experimented with 
Soamin in the treatment of syphilis, and has obtained very favourable results {British Medical 
Journal, Aug. 15, 190a). He has found this drug “ pieferahle to Atoxyl ” from a therapeutic 
point of view. 
At present it is impossible to say much about the action on trypanosomes, but I am now 
engaged in testing it on the trypanosomes of human trypanosomiasis. 
Experiments with ‘So amin’ 
1. Eat (wt. G5 grams): treated Gth day : large infection : ! grain Soamin subcutaneously. 
Result—cured. 
This rat was reinoculated and died of infection. 
2. Rat (wt. 1G7 grammes) : treated Gth day ; large infection : | grain Soamin subcutaneously 
(old solution). Result—died with toxic symptoms on 2nd day. 
3. Rat (wt. 13G grammes) : treated 10th day : large infection : § grain Soamin subcutaneously 
(old solution). Result—died with toxic symptoms on Gth day. 
4. Rat: treated Gth day : large infection : 1 grain Soamin subcutaneously (old solution). 
Result—died with toxic symptoms on same day. 
5. Rat: treated 7th day : large infection : ^ grain Soamin subcutaneously. 
Result—relapse after 20 days. 
Second treatment ' grain Soamin subcutaneously. Result—cured. 
G. Rat (wt. 9G grains): treated Gth day : large infection : ), grain Soamin subcutaneously. 
Result—cured. 
7. Rat: treated Gth day : large infection ; ! grain Soamin in solution by the mouth. 
Result—cured. 
8. Rat : treated Gth day: large infection : ? grain Soamin in solution by the mouth. 
Result—cured. 
9. Rat (41 grammes) : treated Gth daj': large infection : 12'5 milligrams Atoxyl in 1 c.c. 
Result—cured. 
10. Rat ; treated 5th day ; large infection ; 
I grain Soamin subcutaneously — 11th day relapse. 
:J- grain Soamin subcutaneously — 12th day relapse. 
} grain Soamin subcutaneously — relapse and died. 
11. Rat : treated 5th day : large infection : 
! grain Soamin subcutaneously — 21st day relapse, 
grain Soamin subcutaneously — relapse, died. 
