126 



TRYPANOSOMIASIS IN THE ANT, I.n-rri YPTIAN SUDAN 



arc shown in flic aimcxcil fiiMi' (p. 127), ainl it is |iriiiMisiil td iliiil witli cinli cxpcrinnmt in 

 turn ninl tlicii to consiiliT tlic nsnit as u whole. 



In larh instaiirc, with one i-xcuption thie to a niistakr, the Mnuil df the cxiMiiiiicntal 

 animal was canfully cxainini'il prior to inocnlation. 



Exp. 1. Doj,' 1. — Young Shillnk dog, ahont fight months ohl. 

 Jiiniiiini Ht//i, IIKI.'). 4 I'.c. fnsh iiluoil of mnlc injcrti'd subcutiineuiisly. 

 Jiiiiiiiiri/ '22iiil. Trvpanosonifs funnd in the peripheral blood. 

 Ffhruiiri/ Htfi, found dead. 



This dog ran wliat proved to he a very typical conrse for the disease in dogs 

 characterised liy progressive ainemia, weakness and emaciation witii, in tile hiter stages, 

 double corneal opacity. Towards the end the creature hail become a veritable skeleton. 

 The appetite (lid not fail til! just before dcatli and no ucrvous svmptoiiis. except increasing 

 drowsiness, were noted, nor was there aiiv ledema or etliision. 



At the autopsy, the most noticeable feature was a large cll'usicjii into tiic pericardium. 

 Being ill at tlie time I ilid not see tile post-iiiorteui, liut 1 understand ti:at no gastric 

 ulceration and no enlargement of glands was found. 



I believe tliis may iiave lieeii due to the fact tiiat tile dog, a yoniig animal, died at a 



coniparativ(dy early stage in the disease. The blood was noteil as being very thin ami greasy. 



The following is the temperature record from January 30th, taken per rectum, about 



noon of each day, 1028° F., 103°, 102°, 104-6°, 101-6°, 103-2°, 98-8°, 984°, 101-2°. It will 



be noted there was a lowering of the boily lieat towards the end of life. 



Kxp. 2. Dog 2. — Inoculated subeutaneously from Dog 1 on danuary 23rd, about 

 2 e.e. eitrated blood being given. Blood examined for tiie first time on February Itii, when 

 trypanosouies fnuiid. For a few davs prior to fiiis flic dog ii.'id sliown signs of commencing 

 emaciation. At a slightly later period it exhiiiited to a sligiit extent the so-called "bull-dog 

 hea<l " appearance, but this cephalic u-denia passed off", possibly under treatment for this 

 animal was given chrysoidine {vide iufrn). 



Some (edema of the fore-legs and paws was noted on February Otii. imt if was also transient. 

 Double conical opacity was observed on February 12th. Despite treatment the di.>*ease 



progressed and the ilog was found deail, 

 stiff' and colli on the morning of Feb- 

 ruary 20th. 



Post mortem the only thing of 

 note was the enlarged spleen, which 

 measured '.• inclus (23 cm.) in length 

 and ill wiiirli flic f(dlicies were en- 

 larged and prominent. A fuller 

 aeeoiinf of fiiis dog will be found later 

 when tile chrysoidine treatment is 

 discussed. There was no gastric ulcer- 

 ation. The trypanosouies before treat- 

 ment was commenced presented no 

 differences from those found in the 

 mule. Both forms were present. 



( JJixi-ri/ilidiis of ij/ii null Ills n>n- 

 liiiiii'il ml j>. l.3;>.j 



Fig. Sd. Mumikv .Ah^kcikh mum Tkvi'Amosomiams of Mulbs 



