TRYPANOSOMIASIS IN THE ANGLO-EGYPTIAN SUDAN 135 



There was no gastric ulceration. 



In the thorax the periccirdium was foimcl much distended with serous effusion, and the 

 heart muscle was very flabby. The thymus gland was enlarged. 



Although the post-mortem was performed immediately after death, and smears made 

 from all the organs mentioned, no trypanosomes were found — a point to which reference will 

 be made when experimental treatment is considered (p. 155). 



Exp. 7. Babbit 1. — Inoculated subcutaneously with 5 c.c. blood from Dog '2, on 

 18th February, 1905. 



Blood examined 28th February, 1905, with negative results. 



This rabbit became emaciated, but showed no other symptoms of the disease. 

 Trypanosomes were at no time found in its blood, nor was subcutaneous tedema present. It 

 died during the night of March 3rd, and was found already somewhat decomposed on the 

 morning of the following day. Post-mortem digestion of the stomach had set in together 

 with a general bacterial invasion of the tissues. No trypanosomes were found post-mortem. 



I am inclined to think this animal died of trypanosomiasis, and that more frequent 

 examination of the blood would have revealed the presence of the parasites during life. 



Exp. 8. Monkey 2. — Inoculated subcutaneously on February 15th, with about 25 c.c. 

 blood from Monkey 1. 



Blood examined, 21st February, 1905, when it was found to be swarming with 

 trypanosomes of both forms, there being 15 or 20 to each microscopic field. This monkey 

 was also treated with chrysoidine {vir/e p. 155). 



After running a somewhat peculiar course it was found in extremis and chloroformed on 

 March 8th. 



Post-mortem. — Swelling and cedema of the scrotum present in a marked degree. 

 Extreme anjemia of the mucous membranes. Gastric ulceration present, and ulceration at 

 the lower end of the ileum and in the caecum. In the stomach a flat blood clot was found 

 adherent to the mucous membrane towards the pyloric end. On removing it a red congestive 

 stippling was found. Similar congestive patches were present in the ascending colon. The 

 stomach and intestines were preserved for colour museum specimens, and smears were not 

 taken. The spleen was firm and congested ; the liver showed nothing beyond slight 

 congestion ; there was early nephritis present. The brain and cerebro-spinal fluid were 

 examined but nothing peculiar was noted. 



Exp. 9. Dog 4. — Inoculated subcutaneously with 5 c.c. blood from Dog 3 on 

 26th February, 1905. 



Blood examined, March 4th, 1905, when trypanosomes found, about one per field. The 

 temperature taken at noon on tliis day was 104-8 F. Both forms of parasite were present 

 in the blood, and were very lively and active in their movements. This dog was not treated 

 so that its symptoms may be described here. 



Corneal opacity was first noticed on March 11th. It attacked the left eye, the other 

 remaining unaffected at first. On March 22nd, both eyes were found affected and an opacity 

 of the lens of the left eye was noted. The other symptoms exhibited were the customary 

 anaemia, emaciation and drowsiness. There was no oedema. At all times trypanosomes 

 in large numbers and of both kinds were found in the peripheral blood. 



On March 23rd, the dog was found collapsed and cold. There was rigidity of the 

 limbs, and the respirations were laboured and rapid. 



About twenty trypanosomes per field were found, nearly all of the short form, and it 



