156 TllYl'ANDSOMIASIS IN TMK ANGLO-EOYl'TIAN SUDAN 



Feliriitiiy 'I'Anl. 'A ex. given. Six to Iwilvc ]iir ticid. 



Ffliriiiiri/ 'l\tl,. 85 c-.e. given. 



I'lhriiiii-y 'I'uii. t! i-.c. givi n. 



/■'thriiiiri/ '2(>//i. (i f.e. given. No npimrent change. 



FrliriKirii 'llllt. () c.c. given. Weiglit "JSt kilos. 



Feliriiiini •JH^/i. G c.c. given. Jllooil e.xiiniined, no t ry pauosoines founii after a 

 jirolongeil search. 



Mnnh Ixl. (5 c.c. given. Blood examined, a few trypanosonies found. 



Mdir/i 'ln<l. (i e.e. given, as many as four trypanosomes seen in some fiehls. Several 

 motionless and disintegrating forms visilile. 



Miirr/i Wnl. !• e.e. given. No change. 



Miin/i illi. 9 C.C. given. No change. Weight, 25 kilos. 



Miii-rh !Sf/i. !) c.c. given. Not more than two trypanosomes seen per field, iiotli kinds 

 Well shown. Many were vacuolated, vacuoles licing siiecially numerous in the short, Idimt 

 forms. Plate XIV.; Fig.'/. 'I'lir animal aii|i(iiriil tn lie less sleipv, and seemed to lie 

 suffering from itciiinrss as it kept tugging at its coat. 



Miirrh i\lh. Increase in luunlier of parasites. I'rine a marked yellow. 



March Ith. IJIood swarming with jiarasitcs. 12 c.c. given. Weight, 1 kilo. 



March 8//(. Jlonkey in extremis and chlnrofdniicd. 



Although tint r\ panosomes altered somewhat in appearance and for a day disappeared from 

 the peripheral Mood, I do not think the treatment in any way influenced the course of the disease. 



There was no staining of the lirain, spinal-cord or nerve trunks in this case. It does, 

 however, occur when larger doses are given {ri<le iii/ra). 



Exji. !•'•. l)og5. Miinli 'l?u-'l. liloiid contained about 12 trvpanosomes per field. 

 Nearly all were long forms, and they were very active. lU minims (/.<•., •5'.( e.e.) 

 sat. sol. chrysoidine injected intravenously. 



Same dose employed on Mm-rh ^l\th, 'l^)ili and 2(>///, without any efl'ect. Blood 

 swarming with parasites. 



Miircli 27lh. 2(1 m. given. Blood remarkable. 



Trypanosomes agglutinating, many motionless. Remainder sluggish. Within four hours 

 they were all dead and most had broken down into debris. 



Mnnh '2Sth. 211 m. given. Hardly any trypanosomes seen in the fresh blood. After a 

 long search three sluggish forms found in the whole cover slip preparation. A larger 

 number evident in the staint'il tilm, but very few compared with what was found previously. 



March "I'Mh. III! m. given. A slight increase ni the number of trypanosomes. The 

 parasites were sluggish and lackeil definition of (Uitline. Several motionless forms seen, and 

 curious "shadow" forms. Plate XIV. ; Fig, '•. 



Animal very thin and weak. 



March SOth and .Sl.s/. 3U m. given each day. No change. 



.1/))/'/ l--'. Blood in much the same condition. A few agglutinating forms. 20 m. 

 given. In the afternoon the dog was found lying on its siile with neck outstretidied an<l eves 

 fixed. The conjunctival reflex was present. The limlis were rigiil, and every now and then 

 the dog kicked, as it were, with its hind lees. Tim limbs would remain passive and rigid 

 and then be thrown into convulsive movements. Respirations were rapid and noisy. As it 

 was late in the dav when this seizure was developed the animal was chloroformed, kept in 

 the ice chest over-night, and the autopsy performed the following morning. The results of 



