164 TKYPANOSOMIAfilS IN THE ANQLO-EOYI'TIAN SUDAN 



Fi'hruiin/ I'lth, 1906. TrypiiuosoUK'S weri' uguiii iuuiid in the glunds and begun to increase 

 in number in the peripheral blood. Chrysoidine has, therefore, been started once more. It 

 is being given by the niontli in tlu' same doses. The boy's general condition is excellent. If 

 marked improvi'ineiit dues not result it is proposed to exhibit arsenie and trypan red possibly 

 combined with atuxyl. 

 Inoculation Monkey 9. (Cercapithecnx mhceitx). Weight 31 kilos. 



rxperinirnis " . . 



with .Iitue 9tli. Inoculated with 1 c.c. venous and citrated blood from above case. 



.'■"" '">«• fpj^^ blood was examined with negative results down to June 14tli, when the temperature 



of the animal was found to be high. 



June 15//(. Found dead. Poxt -mortem. Pulmonary congestion, and an acute 

 pleurisy were found. There was no evidence of trypanosome infection. Bacterial invasion 

 had occurred. 



Monkey 11. Weiglit -l-l kilos. Tciup. HI4-4 ' ¥. at midday. 



Jiiiii' '2'iiril. Blood examined and foun<l free of any para.site infection. Inoculated fiuni 

 case of Wariga with 8 c.c. venous and citrated blood given subcntaneously. 



./nil/ 1th. Trypanosomes found for the first time. Afternoon temperature 108-3" F. 

 In the interval the temperature (rectal) had ranged from 1U31 ' to lOoP F. There were 

 not many parasites present, but on August 17th an increase in their nnmber was noted by 

 Captain Ensor and Mr. Friedrichs, who were making observations in my absence. 



Sfpteiiilter 5t/i. No trypanosomes were found by Mr. Friedrichs after a long search. 



Si-ptt'inliiT 30/A. One trypanosome was found after a long search. My next note was 

 made on 



Ortotiev 18///, wluii I found trypanosomes present and, as a control, inoculated Monkey 

 18 with ■5 c.c. blood. It may be stated here that this monkey's blood, when examined on 

 November '28th, showed a few trypanosomes. None had been present twenty days previously. 



OrtoliiT 19//(. Tnatiuent with chrysoidine begun on Monkey 11. C4iven I grain (•0(!48 

 gram), Merck's product in 1 c.c. sterile distilled water. Weight, '1 kilos. 



(Ictohi'r 20t/i. Urine yellow. A few trypanosomes present, (i or 7 in tlic staincil film 

 No change apparent in them. 1 grain given. 



Ortobfi- 21x1. Animal did not get a full do.se. About 4/5ths of a grain given. 

 Trypanosomes appeared to be slightly less numerous. (Plate XIV.. Fig. I>). 



(h-tofifr 22)1(1. A distinct diminution in the nnmber of trypanosomes. Only two were 

 found in the film after an exhaustive search. They were ap])arently muliangeil. 1 grain 

 given. 



thloh)-r2^ril. No trypanosomes foiuul after prolonged search. 1 grain given. 



Orloln'i- 2-it/i. Several trypanosomes fonmi in lilin. 1 grain given. 



tirttilii'r 2^illi. Moidvi-y appears to be git ting soincwliat thinner. lilood showed a few 

 trvi)anosomes present which seeme<l to take the stain fe<-bly. 1") grain given. 



<htoIii^2iSlh. As above. Aninnil lively, l'") grain given. 



Ortolirr 27'//. One unaltered trypanosome found after a long search. l'/) grain giv6n. 



Oc.lohi-r 28'//. One film showed no parasites. In a second, one trypanosome was foinid. 

 \'^> grain given. 



( Ir/olirr 29///. One trypanosome fomid in film. TT) grain given. 



I h-tii1ii>r 30///. A drop of blood which exuileil from the needle |)uneture ami was mixed 

 with chrysoidine was examined. The nd rorpnsc les were found to be disintegrated. No 

 parasites were seen. I'G grain given. 



