TEYPANOSOiUIASIS IN THE ANGLO-EGYI'TIAN SUDAN 165 



October 3Ly^. A large tiliu carefully exumiiied. Nu trypauosoiues fuuiiil. 1'5 graiu 

 given. 



Xoveinher Isl. Weight, 2 kilos (uo loss). 1"5 graiu giveu. 



Novemher 2nd. Blood examination negative. Animal well aud lively. 15 grain 

 giveu. 



November Srd to 5tli as above. Chrysoidiue then stopped. 



Novembei i5th. Blood negative. 



Nomiiber 1th. One trypanosoiue fuuud iu film. 



Xovemhev '6th. Blood negative. Urine examined aud uu albumin found. 15 grain 

 given. 



Noneiidier 9lh. No dose given. 



November lOth to 13th. 1'5 grain daily. No trypauosumes fuuud. Myelocytes noted 

 for the first time. Monkey well and strong. 



November lifh to 18//i. Same dose given daily. Occasionally oue trypauusume found 

 per film. Weight on November 18th, 1'9 kilos. 



November IQth. Two grains given. 



November 20th. Two grains given. Blood negative. 



November 'il.s-^ Two grains given. Blood negative. Animal well. 



November 22nd. Two grains daily. One trypanosome found per film on "i'iud and 

 '24th. At this stage considerable auiemia of the mucous membrane, as evidenced by pallor 

 of gums and palate, was noticed. There was some oedema of scrotum and sheath. 



November 25th. Two grains given. Blood not examined. 



November 26tli. No dose given, ffidema of scrotum marked. Weight, 19 kilos. 



November 21th. There was apparently some slight septic infection of the foot following 

 the needle puncture made to secure blood for examination. The mid-day temperature, 

 however, was only 102'8° F. No dose. No albumin in the urine. 



November 2Sth. No note. 



November 29th. Monkey better. Blood negative after exhaustive search. No dose 

 giveu. 



November '30th. One trypanosome found in film. No dose given. 



December 2nd. One dividing form found in the blood. A slight necrotic patch 

 apparent at the common seat of inoculation. Though the animal was well and lively, despite 

 the local sore, it was thought better not to resume treatment. The blood was not again 

 examined till December 20th, when it was found that a distinct increase of trypanosomes had 

 taken place. Four were found in a film after a very brief examination. The monkey looked 

 well, and the wound which had suppurated slightly had nearly healed. 



The animal remains under observation, but I think that, taken iu conjunction with 

 Wariga's case, the results are of such a nature that chrysoidiue might be given an extensive 

 and thorough trial in places where human trypanosomiasis is prevalent. It seems to cause a 

 lessening in the number of the parasites present in the peripheral blood, and the general 

 condition possibly improves under its use. Its tendency to bring on albuminuria is a 

 disadvantage. I admit, however, that no definite conclusions can be drawn from 

 these two cases in man and monkey. Trypanosomiasis due to 7\ ijambiense is generally 

 a very chronic disease, and the action of chrysoidine would have to be observed over long 

 periods, and in a large number of cases at different stages of the disease and under varying 



