170 



TUYPANOBOMIASIS IN Till'. ANOLO-EG YI'TIAN SUDAN 



be ilniwii. Tlu' dilliciiltv is to liiul tiiiio whuiviii tu luiidiRl .sullicii'iit i-xperiiiR'iit.s. Oiif is 

 often iiiti-riupteil by work coining in which iluiniimls immuiliiite attention, imd there is no one 

 lit present to whom sndi wmk ciiii be passed. 



A eonple of iiiiniiiiiising e.xperiiiH'nts were tried. In one the uniinul, ii gerbil, died ; in 

 the other ii jerboii received lU in. of serum tor two (hiys, and tlieii '2U m. every (hiy for eight 

 days, after wliich it was inoeuhited from Monkey 5. After an incubation period of two (hiys 

 trvpanosoines appeared, ami the disease ran its iisuiii cour.-^e wliolly iiiiimidifieil by tlie 

 previous inocuhitions. 



NoTKS (i.N rili: r.\ riKlLOGICAI. .\nATuMV ()!■ 'I'kVI'.\NiiSiiMI.\SI.S. 



Until lialdwiii* in l!tU4 directed his attention to tiiis matter in the ea.se of experimental 

 Nagana it had rect'ived but little attention. Work by Mott.f Warrington| and Low,^ 

 lias been carried out un the coiKJitioii uf tiic brain and cerebro-spiiial Huid.ll Ijavcraii 

 and Mesnil deal with the gross appearances in Nagana, Siiira. ."\Ial-(lr-( 'adcnis, ami tin 

 human disease, and the observers of the Liverpool School of Tropical Medicine have 

 collected iiuudi material, but, so far as I know, Baldwin's remains the most important and 

 coiuidete work out he subject. Since this was written I have seen Mi muir XVI. f of the 

 J.iiverpool School of Trojiical Jledicine, which deals very fully witii the pathology of 

 trypanosomiasis, and is well illustrated. 



As opportunitv ofl'ered I have studied tiie microscopic changes induced in several of tlie 

 organs by the trypanosomes of cattle ami of mules respectively, and a few notes on these 

 observations, which are bv no means exhaustive, may lie of intinst. 'Die sections of live r. 

 spleen, lung, tlivmiis, brain, i\ nipli-Lilands, gastric hiucdus iiiriiilnaiii', and conna have been 

 for the most part stained by the hieiiiotoxyliii and cosini' metliud. The cornea sections have 

 also been coloured by the Gieinsa process. There has not been time to carry out staining 

 by Leishman's new method though it has been tried in one or two instances. 



In the cast' of Ox 4 tin- f(jli(iwing iiarticiilurs were iiottMl. 



/,/■(■/•/•. Theri' was a slight degree of cloudy swelling resulting in a loss of outline of 

 some of the liver cells. These in some instances contained masses of golden-brown pigment 

 which was also present, and to a greater extent, in the endothelial cells. There was marked 

 congestion of the vitKn rnjiilhiria. 



Splet'ii. This presented a very acute congestion of the capillary spaces in the pulp. 



The trabecnhe had undergone hypertrophy as had the Jlalpighiaii corpuscles. Some 

 golden-brown pigment was present in some of the Malpighian bodies, but it was chieHy found 

 in the pulp. 



Liiiitj. Congested. A cellular exudation, chiefly lymphocytic, had taken place into 

 many of the <ilreoll. Others contained a stringy or granular exudate. Certain of the ulveuli 

 were much compressed and in some the walls were in contact. 



Liiiii/>/i-;ihiiii/. An enormous increase of lymiiliiMytcs was noted. Many young blood 

 vessels were present. Large round cells like those met with in thi' mesenteric glamls in 

 cases of enteric fever, and containing fat droplets and sometimes two nuclei, were observed. 



* Journ. of Infect. Dioeasex. ChicaKo; Vol. IV., pp. 544-550. 

 t Brit. Med. .loiirn. Vol. II., p. 1,6GG. 1S99. 

 ; Brit. Med. ,I(,iim. Vol, II,, p. 029, iyo'2. 

 § Low and Mott. Brit. Med. Journ. Vol. I., p. 1,000. 1904. 

 I Mott. Brit. Med. ,Iourn. Vol. II., p. l,.')r>4. 1904. 

 ^ Thonuu and Brienl. Memoir XVI, Liverpool School of Tropical Medicine, 1905. 



