REPORT OF TRAVELLING PATHOLOGIST 201 



eiiils of tliL' *"L-uut;iiuiiig iiieiubmiie uf tlif curpusele are drawn out to tlie finest filament, so 

 fine in some instances that a flagellar-like appearance is caused. The contents uf the 

 corpuscle appear to be under great pressure. At first the wliole is crescent-shaped and 

 uniform in outline, later the pressure against the nucleus creates a lobe in the middle, with 

 an expanded portion bulging on either side ; beyond these again are the drawn out ends and 

 fiagellar-like terminations of the corpuscle. So close does the parasite lie against the 

 corpuscular nucleus that it cannot be distinguished as a separate entity. The nucleus of the 

 parasite [iresents some difficulty. In some cases it appears as if flattened and pushed hard 

 agamst that of the corpuscle, the line uf demarcation being difficult to detect ; in others the 

 staining is so similar to the rest uf the parasite that the outline is difficult to detect. 



In several instances, two of which are illustrated in Plate XX., the parasite is seen 

 ' pushing a portion of itself through the containing membrane of the corpuscle, and appearing 

 as a globular hernia. 



In one of these the corpuscular nucleus is also being extruded, and appears to the eye 

 as if included in the parasite ; in another, the globule is found at the opposite side, and 

 again, in other specimens, the extruded globule is seen arising from either end of the 

 parasite. It is possible that this is the commencement of the globular form described by 

 ]\[. Laveran in the case of Zicinnniii, or the process might be one of ordinary fission, or even 

 perhaps a pathological state induced by shedding of the blood and spreading it out as a film, 

 though I do not think the latter likely. 



It is to be noted that Laveran and Lucet (L'Academie de Sciences, 30tli Oct., 1905) 

 speak of the nucleus being expelled from the corpuscle by II(i:maiiiah<i rcVu-ta.f 



There is a long narrow form, Plate XX., c, without any visible nucleus, corpuscular Long narrow 

 or otherwise, which may be the parasite after parting with one of these globules. 



It will be remembered that Schaudinn has stated that tliis parasite has a trypanosomatic 

 stage (as well as Haltn-iiliinn), and that in that form it attaches itself by its posterior end 

 to an erythrocyte which it then draws into itself. He asserts also that after it has digested 

 the plasma the nucleus is pushed off to one side as an elongated halter-shaped body, 

 eventually to be thrown away as waste. This however, is combated by Novy and 

 McNeal,| who show that trypanosomes are very common in birds, and believe that the 

 occurrence of the two parasites in one blood is fortuitous (viz. H. zieinaniii and trypanosomes) . 

 Although my specimens tend to show that the parasite is endo-corpuscular, yet it is hard to 

 explain why the ends of the containing membrane of the corpuscle should be drawn out to 

 fine points, even resembling flagella. The suggested passage through a capillary is an 

 insufficient explanation. 



The description by |Laveran and his illustrations, as well as those of ||Schaudinn, show 

 in the case of Z'unnanni the nucleus of the corpuscle flattened out, being elongated to at 

 least four times its normal length, so that the ends surround the parasite ; in the case of 

 my films, the parasite surrounds one side and both ends of the corpuscular nucleus, 

 projecting in most cases beyond it at each end to an extent equal to the length of the 

 flattened nucleus. 



* '■ Containing membrane " is a term only used for the purpose of description, though those who argue that 

 such a membrane does not e.\ist should examine this class of specimen. 



t Since writing the aljove I have fouud specimens with the globule just freed from the element. Plate XX. 



X Novy and McNeal. Journal of Infectious Diseases. Chicago, 1st March 1905. 



§ Soc. de Biol., 16th May, 190.3. 



II Arbeiten aus dem Kaiserlicheu Gesundheitamte, Band XX., Heft 3, 1904. 



