and Laboratory Methods. 1509 



Feldbausch has found in epidermoid carcinomas almost constantly a marked 

 increase of the eosinophiles, while in adeno-carcinomas and sarcomas this does 

 not occur. The eosinophiles lie chiefly in the connective tissue surrounding the 

 masses of tumor cells. They form part of the cellular infiltration which owes 

 its origin to inflammatory irritants of chemical, bacterial, or mechanical nature. 

 They are present in greater number in the earlier stages of the development of 

 the tumor, and also in the beginning of inflammations, than later when degener- 

 ation has occurred. 



This investigation throws little if any light on the origin of eosinophiles. The 

 author does not believe they arise in loco. Although he admits that Ehrlich's 

 view that the cells develop in the bone-marrow may be correct, he thinks they 

 may also be formed in the blood. The eosinophilic granules, he holds, are not 

 formed by the ingestion of broken-down red blood corpuscles. The researches 

 of Arnold have shown that the granules belong to the structural elements of the 

 cell, and hence cannot arise through phagocytosis. Eosinophiles are often 

 found in great number in places where no hemorrhage has occurred, and are 

 often not found where destruction of red blood corpuscles regularly takes place, 

 as in the liver and spleen, or where hemorrhage has occurred. j. h. p. 



Edmunds, W. The Pathology and Diseases of Recent researches have shown that the 

 the Thyroid Gland. Lancet, 1: p. 131 7, parathyroid glands are of great im- 

 ^ ■ portance to the organism. Removal 



of these bodies usually causes the death of the animal. The parathyroid glands 

 differ in structure from the thyroid gland in that they consist wholly of cells and 

 contain no vesicles and no colloid, or at most a minute droplet. 



It is not easy to identify the parathyroid glands in the human subject, because 

 some of the minute outlying nodules are found to consist of ordinary thyroid 

 tissue, and to be therefore accessory glands. The anatomy of the parathyroid 

 gland in man has been worked out by Welsh of Edinburgh. He finds that there 

 are four of these glands — one anterior and inferior to, one posterior and superior 

 to, each thyroid lobe. 



Although no symptoms occur as a consequence of the removal of one lobe 

 of the thyroid gland, the other lobe, as pointed out by Wagner, hypertrophies. 

 The vesicles enlarge and become branched, their lining membrane becomes 

 folded, the cubical secreting cells become columnar, and the colloid disappears 

 and is replaced by a mucous secretion which takes the staining reagents badly. 



In dogs, if one parathyroid gland be dissected free from the thyroid lobe, 

 taking care not to interfere with its blood supply, and the entire thyroid gland 

 with, the other parathyroid glands be excised, so that only one parathyroid be 

 left in the animal, the dog will live and no obvious effects will ensue. The 

 parathroid that is left in these experiments shows signs of more active growth 

 than the normal, but it does not develop into thyroid tissue proper. No vesicles 

 form. This disposes of the view once held that the parathyroid glands are 

 undeveloped thyroid tissue. 



Edmunds excised the parathyroids in a number of dogs, leaving the thyroid 

 intact. Interesting changes occurred in the thyroid. The colloid diminished, 

 or completely disappeared, and its place was taken by a watery fluid ; the 



