■12 Oolfific;! Sir Alinrolh t. Wri^fil [Miurlj [), 



III I, lie |;iriiii;i' (>[' viiKriilnriscd Ukkuch W(; liuvt; liv/i .H//fi,rf',.s. In 

 Ui(iH(t w<^ liii,V(; «»|(l,iiiiiiiiir()ii(|il,i<>iiH lor jcKiHl-uiicc to hiw.Loi'iiil \nU:(',l'\()]\. 

 W<i liiivo here nil iiMl-ilnM'l,(;riul lym|»li ; iiiid \>y coiitiiiuouHly renewed 

 (ixiidiiiioii (;orni|tlivc rluiii^^cH will l»i-. ronlJiinjiliy lUilyji^oiiiKcd and 

 niiMJc i^ood. Afjiiin, in live KpuccH we li;i.v<; l,crr:iin (Ji;ii <;iiii Im; 

 (tUVcUvcly H<*-iir('.li(td Wy h-ucoctyl-cH ; iiiid if I. lie liiic.l-criiil inrcciion 

 hIiouM nol, lie, (;xl,iii|^iiiHli('d hy iJic fi)'Kl. Iciii^ocylJc, ul Lark rcinroiTf- 

 nicnl.H (»r |('ii(M)('yl,('H <;iin Im; Hii|t|)lied from I, he ejipilluricK leedin^^ Llic 

 live H|»iM*(!,s. Ill .'ill iJiese, reK|»er,|,s live iiiid de;i,d hjiji,(;<;H iivc Hli;ir|)ly 



Ih'iiil Hiiiuvfi lire round in (jhsiich wliieli luive liee-n lii-niHcd iuid v.nl 

 oil' li'oiii iJieir lilood-Hiijiply, in kIoii^^Iim, in hone s(M{iieHl'ra, iuid in the 

 l,(jxl-ure of cjol/h iUid inl-riiHivc, foniij^n hodieH. And W(i Iim-vc- u dead 

 Hpn.<i<i in ('V<'i'y mI)H<'.(',hh hiu', nnder iwnwy hIon^Ii and Kc-iih, iiiid mIho in 

 (Wc.ry (!oll(!(iion of pnn lyin;^' open in (lie poekcts of ;i wonnd. The 

 <'HH(inl,in,l (tlin,i'ii,el,eriHti(iH of de;id spuces ii,r<! two. P'irHl,, l/h(;y eiinnot 

 Im^ I'lVetiivciy Hen,r<ih(Ml hy leiinocytcH. In Konie (Uihc-h ch(!nil(;ul, in 

 otherH nie(!liiuii<tiiJ, conditioiiH Kland in the way. Secondly, tin; 

 IciH'ocytc-H which iirt! (!n|4'n.}^(Ml (taiiiidt he reinforced, nor c;in the iliiid 

 Ite reiH'wed. Inolation from tla; circulation inakcK this ini|i()Ksihle. 



Lri, me Iry to tell yon in the fewest jiossihh; words what tliis 

 imports in infecti(»ii. If in an infected livtt Kpaxu; the haJaiicc; tnrna 

 in favoiii' of the micioltes, there is still a, cliajice of its l»(iin^ 

 rcdr<'ss('(l. y\t any rate reinforcements can he hroii-jht up. In 

 infected dea.d spaces and let me hei'(; point out to yon that all 

 experiments (;ondiict(;d in t<!Ht-tnl)CS are (-(piivahtnt to experimeiitM 

 conducted in (\v\\{\ spaces an advanta;;c ^^ained l»y the micrrohes 

 is irii'lrie\ ahle. < '(Uiiitcr attack is impossilih;. 



Let me als(i tell yon what hapjieiis to the paiient when iiilectioii 

 lloinishcs 111 a dead space. In tiie first pliice hacterial poisons will 

 he iihsorlied, iiiid the piiticMit will sillVer fl'oin sepiic {vwv. In the 

 ne\"t place the iiiicrohic infection rliis will ^^-nerally he a strepto- 

 coccic iiifectK II, hilt ill wa,r woniids it may he a, ^•aii^'i'ene-hacilliis 

 iiHVctioii will \(i\ often invade the snrronndiii|i,' tissnes and from 

 thence tile hlood sti-eaiii. And in the third placi;, the piis in tliu 

 dead Space will, wlieii it hecoines tryptic, eat its way inl(» tlie 

 <'nclosin^' tissues. Tiie containing' sac will then enlainc in all 

 dimensions, IIk! pus in I he <'ase of an aJiscess hni'rowin,: in the 

 direction of leiist resisliiiK'c iiiilil il opens upon :iii inner or an outer 

 surface. 



'I'li'l'lA'r.MKN'r (»!• \\'()t'\lt iM'IM'riONS. 



If voii li!i\e now (piile cle;iily apprehended (he si<;iii(icant 

 distinctnm helweeii a li\c space :ind a dead space, \oii will with that 

 have mastered the lirst i;reai pi'inciple uoverninn' the ticatmeiit tif all 

 local hact(M'ial iidVctions. If von are dealing- with infection in li\t' 



