ABSTRACTS 689 



Gonorrhea and Its Complications. A. Hyman. N. Y. Med. Jour 



1916, 104, 308-309. 



Twenty-five cases of gonorrhea were treated with the vaccine of 

 Nicolle and Blaizot. Injections were given intramuscularly or intra- 

 venously for 6 to 8 treatments. The dose amounted to 3,000,000,000 

 bacteria and was not increased. Acute cases received injections every 

 day or every other day, chronic cases every two to four days. No 

 local therapy was employed. 



Although 28 per cent of the cases were definitely cured by the vac- 

 cine, the results in general were inconstant. It had no effect upon 

 cases of uncomplicated acute and chronic urethritis. Epididymitis 

 was but slightly improved. Chronic prostatis responded most favor- 

 ably to the treatment and gonorrheal rheumatism improved greatly in 

 a few cases. — M. W. C, 



Toluol: Its Value in the Sterilization of Vaccines Made from Nonsporo- 



genous Gram Negative Bacteria. L. D. Bristol. New York Med. 



Jour., 1916, 104, 360-361. 



Toluol is advocated as an agent for killing vaccines. It does not 

 impair the immunizing power of the vaccine as does heat or strong 

 germicidal chemicals. 



Agar slant growth is covered with toluol and allowed to remain 

 for a length of time necessary to kill. Most Gram negative nonsporo- 

 genous bacteria will be killed in 24 hours. The toluol is then poured 

 off and the cultures returned to the incubator to hasten the complete 

 evaporation of the toluol. Sterihty tests are made and the growth is 

 suspended in salt solution, counted, and employed as a vaccine. 



The staining characteristics of the organisms are retained if the 

 contact with toluol has not been too long. — M. W. C. 



Immunologic Studies on Hodgkins Disease. J. J. Moore. Jour. 



Infect. Diseases, 1916, 18, 569-585. 



An attempt to ascertain whether an immune serum could be pro- 

 duced for this disease. Horses were immunized by intravenous inocu- 

 lation of bacilli isolated from lymph glands. This serum was found 

 to fix complement and to cause marked agglutination. Complement 

 fixation tests made with serum of patients gave in no case inhibition 

 of hemolysis with mixed antigens and vaccination with these organisms 

 failed to increase complement-binding antibodies. Agglutination tests 

 were also negative. Similar negative results were observed in the 

 case of sera from cases of lymphosarcoma, lymphatic leukemia, chronic 

 arthritis and tuberculosis. — P. B. H. 



Bonime's Modification of Koch's Treatment of Tuberculosis. R. C. 



Newton. Med. Rec, 1916, 90, 320-324. 



Bonime's method of treating tuberculosis consists in the frequent 

 administration by injection of minute quantities of tuberculin in 

 gradually increasing doses. The principle is to provide a stimulation 



