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OZENA AND DISTEMPER: COMPARATIVE STUDY OF 



COCCOBACILLUS FOETIDUS-OZAENAE AND 



BACILLUS BRONCHISEPTICUS 



N. S. FERRY AND ARLYLE NOBLE 

 From the Research Laboratory of Parke, Davis and Com-painj, Detroit, Michigan 



Received for publication November 15, 1917 



The question of the relationship of ozena to distemper has 

 been frequently discussed, both in print and otherwise. Many- 

 observers consider the dog a carrier of an organism common to 

 both diseases; and the patients themselves are often of the same 

 opinion as they will frequently volunteer information bearing on 

 their association with dogs, special emphasis being laid on a co- 

 incident infection of the animal with distemper sometime in the 

 early part of the disease. 



Perez (1913) carried out some experimental work along this 

 line and suggested that the infection in ozena probably origi- 

 nates from dogs, and, as a result of his work, cultures from these 

 animals were included in an ozena vaccine upon which Hofer 

 and Kofler (1914), collaborators of Perez, were experimenting. 



Horn and Victors (1916) in this country, considering Cocco- 

 bacillus foetidus-ozaenae (Perez) as the principal etiological factor 

 in ozena and Bacillus bronchisepticus (Ferry) as the cause of 

 distemper, have even attempted to prove a relationship between 

 the above mentioned organisms and claim to have found a posi- 

 tive complement fixation between them. The question, how- 

 ever was left in rather an unsettled condition as may be seen by 

 the following statement made by them: 



''Bacillus hronchisepticus, exhaustively studied by Ferry, M'Gowan, 

 Torrey and Rahe, and determined by them as being the specific or- 

 ganism of canine distemper, morphologically almost identical and bio- 

 logically in many instances similar to the Perez organism, and the 



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THE JOURNAL OP BACTERIOLOGY, VOL. Ill, NO. 6 



