500 N. S. FEREY AND ARLYLE NOBLE 



advanced hypothesis that the infection of fetid ozena is carried by 

 dogs, presents an interesting complex." 



It is not the province of this paper to discuss nor to attempt 

 to offer any proof pro or con as to the etiology of distemper in the 

 dog or of ozena in the human subject (that phase of the question 

 having been taken up by the several authors elsewhere); but 

 rather to attempt to answer the question, as to the relationship 

 of Perez' organism to B. bronchisepticus, which has been so sig- 

 nificantly brought forward by Horn and Victors. 



If Perez' bacillus is the cause of ozena and it is demonstrated 

 to be the same as, or closely related to, B. bronchisepticus, an 

 extremely important point has been established and its bearing 

 on the prophylaxis and management of ozena can hardly be 

 estimated at the present time, since distemper is most widely 

 distributed among dogs and other small animals, especially labo- 

 ratory animals, such as the rabbit and guinea pig. Accord- 

 ingly, the authors, using several typical strains of both organ- 

 isms, have carried on a large number of comparative morpho- 

 logical, cultural and serological tests in an attempt to deter- 

 mine, if possible, the characteristics common or perhaps, to be 

 more exact, not common to both organisms. 



For the morphological and cultural characteristics of B. bron- 

 chisepticus those originally published by one of us (Ferry, 1910, 

 1911) and corroborated by M'Gowan (1911) and Torrey and 

 Rahe (1913) are taken as characteristic; and for Coccobacillus 

 foetidus-ozaenae only those described by Ward (1917) are con- 

 sidered, as they apply directly to the strains under discussion 

 in this work. Unfortunately, there does not seem to be a unan- 

 imity of opinion among writers relative to all reactions of this 

 organism. The question of motility seems to be still undecided. 

 The four strains under discussion, however, were found by the 

 authors to be motile, although not so progressively active as 

 B. bronchisepticus. In this instance the authors do not agree with 

 Ward, who claims that the European strains are non-motile. 



