TOXINS OF BACT. DYSENTERIAE 509 



yielding animals. In comparison however with the non-specific 

 appearance of the symptoms of the exotoxin injection we find 

 that this lack of neutralizing effect of the antiexotoxin serum 

 makes it still more probable that the reaction of the mice after 

 injection of exotoxin must be characterized as a non-specific 

 reaction. 



CONCLUSIONS 



1. Bad. dysenteriae of group III produces both exotoxin and 

 endotoxin. 



2. The endotoxin is the most marked in effect and produces 

 intestinal symptoms in rabbits and mice, while the exotoxin of 

 this group is milder in action, producing pareses in rabbits, 

 while mice react non-specifically to it. 



3. The repeated injections of these toxins over a relatively 

 short period of time render rabbits immune. The sera of these 

 animals show a weak protective action against the homologous 

 toxins. 



REFERENCES 



CoNRADi, H. 1903 Deut. med. Woch., 29, 26. 



D'Herelle, H. 1916 Ann de I'lnst. Pasteur, 30, 145 



Flexner, S., and Sweet, J. E. 1906 Jour. Exp. Med., 8, 514. 



Kratjs, R., and Doerr, R. 1905 Weiner Klin. Woch., 18, 514. 



Kruse, 1907 Deut. Med. Woch., 33, Nos. 8 and 9. 



Neisser M., and Shiga, K. 1903 Deut. med. Woch., 29, 61. 



Phnell, H. 1918 Kliniska och bakteriologiska bidrag till kannedomen ora 



dysenterien i Sverige, Stockholm. 

 Olitsky, Peter K., and Kligler, I. J. 1920 Jour. Exp. Med., 31, 19. 

 Shiga, K. 1898 Centr. f. Bakt., 23, 599. 

 Sonne, C. 1915 Centralbl. f. Bakt., 75, 408. 

 THJ0TTA, Th. 1919 Jour. Bact., 4, 355. 

 Vaillard, L., and Dopter, C. 1903 Ann. de I'lnst. Pasteur, 17, 486. 



