g F i; V i: II. 



Kxi'KltlMKM i'> 

 A full-grown ml. 

 TiMi. Tur. ur WiTM. l(t:„UAItKS. 



I'i M. 130^' ' ■ '"" '■■ (liiriiiR llii' hour. 



1 lit hiu bot'ii for Bomc time very quiet, cvidcntlv soiiii-comatdM' ; nt limeii arouitiDff 



lnTM'lf. Pupild nii>iliTnti'ly contracted. 

 Cot wii» «<( coniul<>»e tliiit an ullenipt wan made to open the head. The finsl incitioa 



wan not noticed ; hut the Hecond umu.'ieil hi r. 

 The pupilB hove heen strongly coutructed, and cut cpiiet and Kemi-comotniie. Kuddenly 

 pupili at once diluted widely, and a severe convuUiou came on. Thi« woa »o •rrer* 

 that I think (lio cat would have died in it. In Ihc midst n( the (It, hnwevi-r. th« 

 skull nas u|ieiied and the thermometer plunged into the bruiu. It iudicalcd lUb F. 



Exi'EKlMENT 16. 

 A yoan}? kitten. 



Tiai. Tar. or Watu. n L.MARKS. 



I:tOr. M. ITtPF. 



1:j5 Kitten hn.s lieen semi-comatose, with strongly conlmcted pupils, for pome lime. Kud- 



denly its pupils diluted, uiid a general epileptilorm ronvulsion, rommencing in tb« 

 mu.scle8 of the jaw, sot in. In the niid!<t of this the tluTniometer was plunge«l iuto 

 the brain. It indicated lOT^..") F. 



riio only olijcrtiou of iiuy forrc wliicli I can iniaf,'iiic capable of Ixiufj raised 

 tiffaiiist the coiulusion drawn from the previous experiments is, that the resiihs 

 were not really «lue to the immediate action of the heat, but to a determination of 

 blood to the head and consequent conjjestion of the brain. 



The want of v;ilidity of this objection is apparently demonstrated liy the following 

 facts: — 



1. Sudden epileptiform convulsion is not generally the result of congestion of 

 the brain. 



'i. Opening the skidl through the longitudinal sinus, although necessarily allorti- 

 ing immediate relief of any existent congestion, did not stop the convidsion. 



3. .\bstraction of the heat by pouring cold water over the head, sufficed to 

 produce immediate cure. 



It having been proven that the local application of heat fo the brain will produce 

 the cerel)ral phenonn iia ixhiltited when the brain n aches a febrile teni|)erature, it 

 is next in order to study the relation of the heart to fever heat. I have made no 

 experiment.s upon this subject, such having been rendered unnecessary by an 

 adntirable paper by Dr. T. Lauder Brnnton (.SV. Burfliolomcir'/t Jfi>»/>l/ul Rejiortt, 

 vol. vii.). lu this memoir it is shown that when the cut-out heart of a frog is 

 exposed to a rising temperature, the ciirdiac pidsations constajitly become more 

 and more rapid initil a heat limit is nearly reached, at which the action of the 

 heart ceases. The increase in the rapidity of the movements of the heart is not in 

 direct relation to the increment of temperature ; at first the increase of movement 

 is slow, but the rapidity of the increase becomes more and more rapid as the titn- 

 perature rises until the maximum rate is reached. Pauum has found that the cut- 

 out heart of the rabbit responds to heat in the same way as does that of the frog, 

 and Urunton has experimented by bringing the rabbit profotuidly under the influ- 

 ence of chloral, and tin n surroiuiding him with a jacket of ho: water. These 



