A STUDY IN MORBID AND NOKMAL I" Jl Y S I () L () (; V, 



14' 



Experiment 101. 



A dog. Curari giveu; artificial rcspiratiou; vagi dividwl; splaiicljiiics cut just above the 

 diaphragm, as shown by autopsy; sciatic iicrvu e.xposcd. Some hcmun-hagc occurred during the 

 operation and further lowered the blood pressure. 



Time. Aktkrial PKESiURE. Ikejtation. REMAHKS. 

 Sec. (JMillimetres.) 



li 



10 11 Current applied. 



15 15 



20 20 



25 2G 



30 24 



35 24 Current broken. 



40 18 



45 16 



50 15 



55 13 



Time. Arterial Pressure Irritation. REMARKS. 



Sec. iMillimetres.J 



11 Current applied. Fig. 1, Plate IV. represents the tracing of this K.tperiment. 



5 17 



10 20 



30 24 



40 26 Current broken. 



45 22 



50 18 



60 14 



Detailed discussion of these experiments is not necessary; they prove that, 

 although the influence of the splanchnics upon tlie force of the blood current is 

 very great, after their section irritation of a sensitive nerve is still capable of pro- 

 ducing a rise in the arterial pressure, and that consequently the arterioles, otlicr 

 tlian those of the abdomen, play at least some part in the determination of the 

 blood pressure. 



With this knowledge the next step in the investigation was to discover whether 

 either irritation or destruction of the special region of the brain cortex, which is 

 connected with the thermic functions of the body, has any influence upon the 

 arterial pressure. 



Experiment 102. 



This dog liad lieen used in the second fever experiment, but except for some embolic (?) lameness 

 seemed well. Curari given; artificial respiration; femoral artery used; trephine opening upon 

 each side over the Hitzig's centre; vagi not cut. 



Time. Arterial Pressure.* REMARKS. 



H. M. Sec. 



2:48 P.M. 215-220 



2:49 21.")-230 



2:49:10 21.5-225 Brain surface in Ilitzig's regions mechanically destroyed. 



2:49:20 205-220 



* In the experiments marked with an asterisk, the scale of the instrument with which the pres- 

 sures were taken was an arbitrary one ; the number.s therefore rejiresent units, whoso exact value I 

 am not now able to give. As each experiment is a relative one and complete in itself, this omission 

 does not affect the conclusions to be drawn from the series. 



