1,;,; Ki;vi:i:. 



Thf conclusiiins wliidi Senator ilraws from liis own oxporimonts, and tlu> invcstij^a- 

 tioiis of LirlMrinfistcr anil Li-yikii arc: lliat tlii* dissipation of heat is dnrin^ tlio 

 tliill of tarly frvir Icssi-nrd, n»)t incrrasfd ; but that it is increased ilurin<( tlic 

 height of the fever, sonietirues us nmcli as 10-75 per cent., and still more at the 

 critical febrile decline. 



I think a doso study of the table, just f,'iven, will Inrdly liear out this conclusion 

 ns bein<j fairly derivable from it. 1 shall not, however, discuss this in detail, 

 U'cause the method of experimentation of Senator seems to me open to such falla- 

 cies as to rob it of much of its authoritativcness. The rhythm of animal thermo- 

 metry, especially in septic disease, indicates a corresponding; rhythm in heat pro- 

 duction. Now, it is most probabl(\ that in septic fever this rlnlhm is very different 

 from what it is in the normal state. Hence, comparisons of the fever and normal 

 heat product, made over an hour or so in the twenty-four hours, must yield doubttul 

 results. The comparison should be made for the whole day. For this and other 

 reasons, which it is not necessary to discuss in detail, it has seemed to me that 

 the experiments of Senator are an insufficient basis fur answering the question ns 

 to heat j)rodnction in fever. 



For the purpose, if jmssible, of finally solving this first problem in the nature of 

 fever, the following experiments were undertaken: — 



EXTERIMKNT 110. 



A male ailult cur. AYciglit 11. h •rounds. 

 August 2. 



1:1;') 1'. M. — .\to one j)ouii<l of raw liver, limps, and neart of sheep. 



(Rain) 

 7:3A P. M.— Rectal temperature 39^ C. 1 102'. 2 F.). 



