23G 



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niiumiit of heat, tin- txjHTiimiit shows that tlio liiglicst (hvi htpmcnt of the fever 

 iiroeehs may occur when the teiii|ierature is lowest; or, in other words, the «X[Mri- 

 nuMit demonstrates, that excessive nutritive actions aecompanii d l»y an inordinate 

 h«'at production may occur in a fehrih- disorder althou«,'li the general hoilily temjM-- 

 rature remains low. It also throws liglit upon the apparent subsidence of fever 

 sometimes seen shortlv before death in low feorihr diseases, showing that an exces- 

 sive heat dissipation may iiitirely mask an excessive Inat pro«luction. 



In Experimi'iit llti, the animal was a raidtit ; the food day was really one of 

 partial feeding, but the heat production was decidedly less than on the fever day. 

 In Kxprriment ll.'j (not in tlie table), in which the trial was only during a few 

 hours and llu- animal a rabbit, the production of heat was in slight excess alter the 

 full formation of tiie febrile period, although it was apparently diminished during 

 the forming period of the fever. (See j)age '2'i;V) 



The experiments upon dogs, which have just been detailed, are in close accord 

 with those of Senator. 1 think the following conclusions must be considered as 

 demonstrated: In the iti/ftntlc /ircr of (hufH the heal jirinhiH'uin w iixwillij in tjrnfH 

 of (he halt prixliiclinit of j\ix(in<j dui/H, but ItM tlntn Ihnl uhlih rtnt. In- jinKhuxl iij 

 hiijh fifffin;/ : iiJ<it<illi/ (he prodii.clion of animal hmt ri^cH in (he fthrilc ndde ui/h 

 (he (iiiijM ntdire anil irith (lie Mivjc of (he f rcr, hn( somttitnrx (he he<t( prniliicdon 

 fwvonieit Ctrl/ cxeessire, aUlioii Ji (he (cwpcrndire of (he hoiiy nvntlnti neitr (he nor- 

 mal liini(. In ruhhidi ici(h pi/amic ferer htai pro<liic(ioii seeinti (o Ik- creu ijrcaltr 

 (hun i( ix in hmllh irhe i food in (aheii. 



In studying the production of animal heat in the normal dog it was found that 

 there are evidently two sources of it; a portion of the heat being ])roducrd l>y 

 the immediate destruction of food taken in excess of the needs of the organism ; 

 and another portion being the result of chemical movements in the stored materials 

 of the body. The experiments upon pya-mic dogs, which have been detaih d, show 

 that whilst in fever there is little or no ingestion of food and conse«|uently little 

 or no production of heat from such source, the heat develojied by the ciiemical 

 movements of stored materials in the body is increased or, in other words, that there 

 are increased chemical movements in tiie tissues during pyirmic fever in dogs. 



In rabbits the eft'ect of the immediate ingestion of food upon animal tem|M'ratnre 

 is much less than it is upon dogs, and for obvioiis reasons: the digestion of such 

 food as hay is a very slow process, taking hours, ])erhaps days for completion, and 

 the excess in the lilood of nutritive material at any one time is not so marked as it 

 is in dogs, which will eat, at one meal, as much of meat as ;"> per cent, or more of 

 their entire weight. The two ex])friments upon rabbits detailed are, however, in 

 accord with tlie conclusions reached in doijs, for in both of th«-se e\i)erimenfs the 

 heat production was in excess during the felirile state of what it was wluii there 

 was no fever and when food was taken freely. 



It is a matter of the greatest interest to compare these results with those 

 reached by Lic-bermeister and by T.ey«len in man. liefore doing so, however, it 

 Rcems best to see how far tlifv tally with those which have been reached by the 

 dedujtivc method as I have termed if; «. r., by calcidations l)ased upon the ingestn 

 and egesia of fever. The ablest and fullest discussion of this evidence with which 



