'240 



|- !•; \' i; u , 



sition with llu' vital part of llit- ton< lusioiis derived frdiu the cxiiiriiuciits detailed 

 in this meinoir; in fact they are eiirnjl)oralive of the leadinj,' fact eslahlislied hy 

 iho i»re.sent researcli, namely, that in pya-niic fever in do;^'s and rabbits the linuhi- 

 inental portion of the diseuso-proccss is an increase; in lieat prodnetion by chemical 

 movements in the aceumnhxted material of the organism. It is tru«' that 1 nsnally 

 foiMid that this increase was not snf!i(i«'nt to overplus the luss of produetiDii from 

 nlistinencc from food, but sometimes it was more than suiheieiit. It is possible 

 that the conclusion of Liebernieister and Lcydiii [that in man there is an absolute 

 increase in heat |)roduetion; or, in other words, that the overplus of tissue-heat 

 is more than sutlicient to overcome the loss of food-heat] is substantially correct, 

 as a general law, althou:,'h it cannot be admitted that it is demonstrated or without 

 exceptions. The feiirile movemi'uts in man are much more pronounced and .severe 

 than those of the animals experimented upon by myself. A rise of 10 l-'ah. is not 

 very rare in man, one of 7^ Fall, xcry common, and one of 14° by no means unheard 

 of. In dogs and rabbits I have rarely, if ever, seen a rise of more than 4", except 

 npon exposure to direct heat, and the usual ch^vation of fatal pynrmic fever has 

 not been '.i . Under these circumstances it would not be surprising if the overplus 

 of tissue heat production were greater in man tiian in animals. However this nuiy 

 be, ami future human calorimetrical experimentation can alone determine it, it 

 seems almost certain, that, whatever may be the usual course, human, as well as 

 canine, elevation of bodily fem]K'raturc may occasionally coexist with diminished 

 heat production as compared with that of high feeding; and that the tenip<rattire 

 of the body is the residt of the play between heat dissipation and pro luction. 



It seems to me certain that what is habitn;d in tlie lower animals is at least 

 occasional in man, and that elevation of temperature may at times coexist in man 

 with diminished heat jiroduction, and that lowered or normal temperature may co- 

 exist with increased tissue metamorphosis or chemical movements. Most practi- 

 tioners of medicine have seen cases of increased tissue change as shown by emaciation 

 and excessive urea secretion without elevation of temperature; or fever cases in 

 which the temperature seemed so out of proportion to the results upon the bodily 

 tissues as to ii;dicate irresistibly that heat retention was playing an important part 

 in ]>ro<lucing the fever; or collapse coming on in fevers when the sudden fall of 

 temperature seemed inexplicable by any theory other than a sudden loss of heat. 



In conclusion it appears to me that the following proposition is demonstrated for 

 dogs anil rabbits, and practically assured for man. 



Fcvir w a rnt/ijtlir nnlril'irv fliMhirfiiiiire in irli'nh (hire i» an rxcf^ixiic jumliirtinn 

 of Kurh jHtrl'inii of thr /hhH/i/ liiat an w tJcriral Ji'dii vhruiirnl i)ii>reiiiriil» in the 

 wriiuiiiliilnl iiniti rl<i/ itf thi' nrt/duiMin, Ihr nnrpJus Ininij nomrdwr/i /<v«, nomitiiiira 

 vinrr than the Itts/i of Inat prfahirtion rtxiiltinif from nlmtinrnre from fifxt. The 

 ill jrir of IhmHIi/ tfmjM raliin- in fmr (hjwmls, in ijniiti r or lixf jnrtinurr, ti/>nii u 

 ili^/nrfiiinrc in the nultinil jitui/ lulirptn the fiim-tinni of hnit prtx/tu'lion ami htnt 

 <liMi>ijnition, un<1 is not an arm rate mtiuaire of the inUnnifi/ of' (he iucrcawd vhemicul 

 vtorements of the lisMiua. 



IJefore leaving this portion of the subject I cannot refrain from calling aftenti<m 

 to the strong corroboration whiih this proposition receives from a study <»f cim i- 



