A STUDY IN MORBID AND NORMAL PHYSIOLOGY. 



243 



KxPEItniENT 113 



Heat Rectal 



Pruductios. Tesipeeatcre. 



(Fah.j 



1I:32p. M. to 0:32 A.M. 118.0278 104O.7 to lO'P.S 



10:51 A.M. to 12:51 P.M. 115.3317 104.1 



4:32 p. .M. to 10:32 p. M. 112.1112 100.7 to 104.7 



Expehime.nt 110. 



T^i^is Heat Rectal 



Production. Temterature. 

 (Fah.) 



ll:27r. M. to 5:27 a.m. 23.3231 104O.7 to 103O.8 



7:11 A. M. to 12:11 p. m. 14.7302 10.3.2 to 105.8 



1:17 p.m. to 3:17 p.m. 14.4552 102.2 to 103.6 



4:31 p. M. to 10:31 p. m. 30.1220 105.4 to 104.5 



It will be seen that in Experiment 110 the production of heat was at its maxi- 

 mum in the evening, and regularly diminished towards a minimum in the morning. 

 In Experiment 111 the same regular course was followed. In Experiment 112 the 

 record is irot so concordant, the maximum heat production not being reached until 

 after ten in the evening. In Experiment 113 the maximum lieat production was in 

 the early mornnig, the minimum in the evening, the difference between the maximum 

 and minimum being, however, very trifling; whilst in both Experiments 114 and 

 116 tlie course was a perfectly regvilar one from an evening maximum to the morning 

 minimum. Out of the six experiments, therefore, four are in close accord, one is 

 somewhat discordant, and the sixth absolutely reversed. It is remarkable that in 

 the experiment last quoted the usual evening rise of temperature occurred althougji 

 the heat production suticred no increase. It should be noted, that in tlie discor- 

 dant experiment, the difference between the minimum and maximiun produc- 

 tion of temperature was very slight: that the rhythm of evening and morning rise 

 of temperature was almost absent, and that an injection of putrid blood into the 

 jugular vein was practised just before the animal was first put into the calorimeter. 

 The latter fact probably offers the key of the difficulty, the pus acting immediately 

 upon the bodily functions and thereby deranging both rectal temperature and heat 

 production. In such a disturbing cause is found sufficient reason for not allowing 

 much weight to the exception to the general law outlined in the more accurate 

 experiments, or rather in the experiments performed when the pyaemic fever was 

 fully developed and running a steadier, more typical, and less interfered with 

 course. "While, therefore, the experiments cited show tliat the law enunciated 

 below may not be absolute and cover all cases of pyaemic fever, it does not invali- 

 date it as the normal expression of a typical pyasmic fever. 



In pyaemia stq^erindNcaJ in do'j-'^ and ralMffi there is imiaUy an evening rise of 

 tlie hodihj temperature wliich is consent ancotis icilh an increase of the production of 

 licat in the organism. 



