12 THE TONER LECTURES. 



prepared to deny ''that transformations of the true gland tissue 

 of the parts involved play a certain role in producing tlie tex- 

 ture of cancerous growths." But just how far the normal ele- 

 ments are atrophied and perish, and how far at times an ill 

 directed formative activity may lead to their monstrous develop- 

 ment, — these are matters on which I said that it was difficult 

 at present to form a judgment. 



At the time I wrote that report I had not 3^et read the paper 

 of Classen. I ought to have read it, I know, for the number 

 of the journal containing it had passed through my hands. 

 Still somehow it escaped me, and 1 did not come upon it till a 

 month or two after the publication of my report. Now that I 

 have carefully studied it I am more than e\er impressed with 

 the importance of the part taken by migrating white corpuscles 

 in the genesis of cancerous groM'ths, but I get no help from 

 Classen with regard to the difficulty just indicated. The case 

 he so carefully describes is one of a growth in a non-glandular 

 part, and it leaves unsolved the question of the behavior of the 

 gland lobules when glands are the seat of the morbid growth. 



In June, 1872, Professor Waldeyer published in Virchow's 

 Archiv, a second article on the development of carcinoma,* 

 in which, with all the light of recent discovery, and after a 

 careful revision of the whole subject, he nevertheless substan- 

 tially reaffirms the views of his first paper. He now admits 

 indeed that the elements of the small-celled brood are migrated 

 white corpuscles, and that Koester's view, that the cancer cyl- 

 inders lie in the Ij^mphatic passages, is very often correct ; but 

 he still holds firml}^ to the doctrine that the cylinders them- 

 selves are always outgrowths from some normal epithelial 

 structure with which they yet retain their connection. He 

 supports his opinion by many new^ and carefully described 

 details, and by a critical review of the modern literature of 

 the subject. His paper is illustrated by a number of careful 



* Virchow's Archiv, Bd. 55, S. C7. Die Entwicklung der Carcinome. 



