18 THE TONER LECTURES. 



wish particularly to insist upon the luxuriant small-celled 

 brood about the terminal buds, which is still better shown in 

 the second photograph, in which a higher power has been used. 

 (Two photographs, Nos. 19 and 20, shown.) 



I draw my next illustration from a case of epithelial cancer 

 of the lip, excised from a man about forty-five years of age. 

 A smaller growth had been previously destroyed by caustic, 

 but the disease had recurred in the cicatrix, and was removed 

 by the knife in February, 1871. 



The general anatomy of the morbid growth was that of an or- 

 dinary epithelial cancer, and I shall not go into its details ; but 

 some sections, cut at its edge parallel to the anterior surface of 

 the lip and transversely through the hair follicles of the beard, 

 are so instructive that I have made photographs from them. 



These sections show that in the progress of the disease the se- 

 baceous glands and the hair follicles are transformed into can- 

 cer tissue, but they show also that, for some distance be3'ond 

 the point to- which outgrowths, actually continuous with the 

 cancer, can be traced, an infiltration of small cells, apparently 

 corresponding in its distribution to the course of the blood- 

 vessels, exists in the connective tissue between the hair follicles. 

 It is difficult to resist the conviction that this small-celled infil- 

 tration represents the first step in the morbid process, and 

 ultimately contributes its share to the building up of the can- 

 cerous mass. (Six photographs, Nos. 21 to 26, shown.) 



I exhibit next a view of a section through the mucous mem- 

 brane of the lip in the immediate vicinity of another epithelial 

 cancer. On one side the preparation shows one of the labial 

 glands in a nearly normal condition ; those of the lobules of 

 the next gland which are nearest the cancer are swollen, opaque 

 and fused together ; all the lobules of the next gland have 

 undergone the same change ; the next two glands are trans- 

 formed into opaque cell masses in which no trace of the lobules 

 can be discerned- These transformations of the gland tissue 



