KEPARATORY INFLAMMATION IN ARTERIES. 49 



them to thrombosed arteries. He admits, in a general v>ay, 

 the conclusions of the latter, but while stating that he has 

 found the vermilion granules in the midst of the blood-clot in 

 the carotid arteiy of a rabbit, he sa^'s that they are free^ i. e., 

 not contained within the body of leucocytes. Rindfleisch also 

 accepts BubnofTs conclusions. Tschausoff has repeated the 

 experiments of Bubnotf, and has declared that he has been 

 unable to confirm the observations of the latter. Durante, 

 after an elaborate series of experiments, contests the conclusions 

 of Bubnoff {vide pp. 15, 16), as also do Cornil and Ranvier. 



Thus we have seen that not only have the observations of 

 Bubnoff concerning the source of the organizing elements of 

 the thrombus failed to receive exact confirmation by the ex- 

 periments and observations of any one of the previously 

 named investigators, but that, on the contrary, no less than 

 five most excellent observers, after carefully repeating and 

 somewhat extending his experiments, have flatly contradicted 

 him in many important particulars. 



It therefore seems to me that, in the face of these negative 

 results and positive assaults, neither the observations and con- 

 clusions of Bubnoff, respecting the migration and functions of 

 the white blood-corpuscles found in the lumen of the ligated 

 vessels, nor the theories of others based thereon, should stand 

 for one moment. 



We are, then, forced to the conclusion that if any leucocytes 

 at all have wandered into the clot, the}' could only have come 

 from the blood in the lumen of the artery above the throml)us. 



As to the function of the leucocytes found in the blood or 

 fibrinous clot, it is so nearly nil, as we have already seen, that 

 whatever it may be it cannot save that clot from inevitable 

 destruction. As to whether or not those leucocytes found in 

 the plastic clot have any mission to perform, I have no facts to 

 ofTer, and therefore refrain from advancing assumi)tions. 



"We next iiupiire into the genesis of those colorless cells 

 4 



